In vivo modulation of myelin gene expression by human recombinant IL-2

Maria Sessa, Raffaello Nemni, Sandro Iannaccone, Angelo Quattrini, Valeria Confalonieri, Nicola Canal

Research output: Contribution to journalArticle

Abstract

We treated adult mice with human recombinant interleukin-2 (IL-2) and determined the expression of the genes encoding for the major central and peripheral myelin proteins. In the CNS, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) mRNA levels were the same both in IL-2-treated and in control mice. Proteolipid protein (PLP) transcript was decreased in IL-2-treated animals when compared to controls. In the PNS, the messages for the glycoprotein P0 and for MBP were markedly increased in IL-2-treated animals when compared to controls.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalMolecular Brain Research
Volume12
Issue number4
DOIs
Publication statusPublished - 1992

Fingerprint

Myelin Sheath
Interleukin-2
Gene Expression
Myelin Basic Protein
Myelin P0 Protein
Myelin-Associated Glycoprotein
Proteolipids
Myelin Proteins
Messenger RNA
Proteins

Keywords

  • Interleukin-2
  • Myelin
  • Myelin gene
  • Oligodendrocyte
  • Schwann cell

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

In vivo modulation of myelin gene expression by human recombinant IL-2. / Sessa, Maria; Nemni, Raffaello; Iannaccone, Sandro; Quattrini, Angelo; Confalonieri, Valeria; Canal, Nicola.

In: Molecular Brain Research, Vol. 12, No. 4, 1992, p. 331-334.

Research output: Contribution to journalArticle

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AU - Canal, Nicola

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