In vivo neurochemistry with emission tomography and magnetic resonance spectroscopy: Clinical applications

Angelo Del Sole, Anna Gambini, Andrea Falini, Michela Lecchi, Giovanni Lucignani

Research output: Contribution to journalArticlepeer-review


The assessment of neurochemical processes in vivo has received much attention in the past decade as techniques such as positron or single photon emission tomography (PET and SPET), and magnetic resonance spectroscopy (MRS) have become more available. With PET and SPET, basic processes, such as blood flow and oxygen or glucose metabolism, can be regionally assessed, along with more specific functions such as the production, release, and reuptake of neurotransmitters and their occupancy of specific receptors. At the same time, MRS can reveal changes in concentration of several hydrogenate compounds in the brain. All these methods have been extensively applied for research in neurology, and some applications have reached the clinical level, namely for the study of degenerative diseases, motor-neuron diseases, movement disorders, cerebrovascular diseases, and epilepsy. This article focuses on the most relevant information that can be obtained with these complementary techniques to help clinicians in the assessment of neurological diseases.

Original languageEnglish
Pages (from-to)2582-2599
Number of pages18
JournalEuropean Radiology
Issue number10
Publication statusPublished - Oct 1 2002


  • Alzheimer's disease
  • Epilepsy
  • MR spectroscopy
  • Neuroimaging
  • Neurotransmitters
  • Parkinson's disease
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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