Abstract
The assessment of neurochemical processes in vivo has received much attention in the past decade as techniques such as positron or single photon emission tomography (PET and SPET), and magnetic resonance spectroscopy (MRS) have become more available. With PET and SPET, basic processes, such as blood flow and oxygen or glucose metabolism, can be regionally assessed, along with more specific functions such as the production, release, and reuptake of neurotransmitters and their occupancy of specific receptors. At the same time, MRS can reveal changes in concentration of several hydrogenate compounds in the brain. All these methods have been extensively applied for research in neurology, and some applications have reached the clinical level, namely for the study of degenerative diseases, motor-neuron diseases, movement disorders, cerebrovascular diseases, and epilepsy. This article focuses on the most relevant information that can be obtained with these complementary techniques to help clinicians in the assessment of neurological diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 2582-2599 |
| Number of pages | 18 |
| Journal | European Radiology |
| Volume | 12 |
| Issue number | 10 |
| Publication status | Published - Oct 1 2002 |
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Keywords
- Alzheimer's disease
- Epilepsy
- MR spectroscopy
- Neuroimaging
- Neurotransmitters
- Parkinson's disease
- Positron emission tomography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
In vivo neurochemistry with emission tomography and magnetic resonance spectroscopy : Clinical applications. / Del Sole, Angelo; Gambini, Anna; Falini, Andrea; Lecchi, Michela; Lucignani, Giovanni.
In: European Radiology, Vol. 12, No. 10, 01.10.2002, p. 2582-2599.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo neurochemistry with emission tomography and magnetic resonance spectroscopy
T2 - Clinical applications
AU - Del Sole, Angelo
AU - Gambini, Anna
AU - Falini, Andrea
AU - Lecchi, Michela
AU - Lucignani, Giovanni
PY - 2002/10/1
Y1 - 2002/10/1
N2 - The assessment of neurochemical processes in vivo has received much attention in the past decade as techniques such as positron or single photon emission tomography (PET and SPET), and magnetic resonance spectroscopy (MRS) have become more available. With PET and SPET, basic processes, such as blood flow and oxygen or glucose metabolism, can be regionally assessed, along with more specific functions such as the production, release, and reuptake of neurotransmitters and their occupancy of specific receptors. At the same time, MRS can reveal changes in concentration of several hydrogenate compounds in the brain. All these methods have been extensively applied for research in neurology, and some applications have reached the clinical level, namely for the study of degenerative diseases, motor-neuron diseases, movement disorders, cerebrovascular diseases, and epilepsy. This article focuses on the most relevant information that can be obtained with these complementary techniques to help clinicians in the assessment of neurological diseases.
AB - The assessment of neurochemical processes in vivo has received much attention in the past decade as techniques such as positron or single photon emission tomography (PET and SPET), and magnetic resonance spectroscopy (MRS) have become more available. With PET and SPET, basic processes, such as blood flow and oxygen or glucose metabolism, can be regionally assessed, along with more specific functions such as the production, release, and reuptake of neurotransmitters and their occupancy of specific receptors. At the same time, MRS can reveal changes in concentration of several hydrogenate compounds in the brain. All these methods have been extensively applied for research in neurology, and some applications have reached the clinical level, namely for the study of degenerative diseases, motor-neuron diseases, movement disorders, cerebrovascular diseases, and epilepsy. This article focuses on the most relevant information that can be obtained with these complementary techniques to help clinicians in the assessment of neurological diseases.
KW - Alzheimer's disease
KW - Epilepsy
KW - MR spectroscopy
KW - Neuroimaging
KW - Neurotransmitters
KW - Parkinson's disease
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0036781030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036781030&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 2582
EP - 2599
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 10
ER -