In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors

Paolo Malatesta, Paola Sgadò, Luca Caneparo, Giuseppina Barsacchi, Federico Cremisi

Research output: Contribution to journalArticle

Abstract

The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalDevelopmental Brain Research
Volume128
Issue number2
DOIs
Publication statusPublished - Jun 29 2001

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Keywords

  • Asymmetric cell division
  • In vivo
  • Neural stem cell
  • Neurogenesis
  • PC3
  • Retroviral vector

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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