Abstract
The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.
Original language | English |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | Developmental Brain Research |
Volume | 128 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jun 29 2001 |
Keywords
- Asymmetric cell division
- In vivo
- Neural stem cell
- Neurogenesis
- PC3
- Retroviral vector
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience