In the Anturane Reinfarction Italian Study the trend of some specific and quantitative hemostatic parameters is being investigated in different series of patients balanced for sulfinpyrazone and placebo. In a series of young male patients who had had myocardial infarction 6 months previously, it has been shown that the placebo treatment subsample presented shortened platelet production time (PPT), increased levels of plasma β-thromboglobulin (β-TG) and platelet factor 4 (PF4), and increased factor VIII related antigen (VIII:RAg) compared with a matched control group. A close correlation between plasma concentration of VIII:RAg and PPT was evidenced in the same treatment subsample. The sulfinpyrazone treatment subsample presented normalized PPT accompanied by reduction of VIII:RAg but not of β-TG or PF4 levels.
|Number of pages||9|
|Journal||Scandinavian Journal of Haematology|
|Publication status||Published - 1981|
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