In vivo platelet hyperactivity and factor VIII related antigen increase long after myocardial infarction. A controlled effect of sulfinpyrazone

M. Cortellaro, C. Boschetti, P. Beggi, E. E. Polli

Research output: Contribution to journalArticlepeer-review

Abstract

In the Anturane Reinfarction Italian Study the trend of some specific and quantitative hemostatic parameters is being investigated in different series of patients balanced for sulfinpyrazone and placebo. In a series of young male patients who had had myocardial infarction 6 months previously, it has been shown that the placebo treatment subsample presented shortened platelet production time (PPT), increased levels of plasma β-thromboglobulin (β-TG) and platelet factor 4 (PF4), and increased factor VIII related antigen (VIII:RAg) compared with a matched control group. A close correlation between plasma concentration of VIII:RAg and PPT was evidenced in the same treatment subsample. The sulfinpyrazone treatment subsample presented normalized PPT accompanied by reduction of VIII:RAg but not of β-TG or PF4 levels.

Original languageEnglish
Pages (from-to)106-114
Number of pages9
JournalScandinavian Journal of Haematology
Volume26
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Hematology

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