TY - JOUR
T1 - In vivo preclinical evaluation of the influence of osteoporosis on the anchorage of different pedicle screw designs
AU - Giavaresi, Gianluca
AU - Fini, Milena
AU - Giardino, Roberto
AU - Salamanna, Francesca
AU - Sartori, Maria
AU - Borsari, Veronica
AU - Spriano, Silvia
AU - Bellini, Chiara M.
AU - Brayda-Bruno, Marco
PY - 2011/8
Y1 - 2011/8
N2 - We investigate the anchorage of pedicle screws with different surface treatments in osteoporotic bone. Eight ewes were divided into two groups of four animals each: four sheep underwent bilateral ovariectomy (OVX Group), whereas the operation was simulated in the remaining group (SHAM Group). Eighteen months after the first operation, the Dynesys® System was fitted to the sheep using pedicle screws with three different surface treatments: untreated, rough blasted (uncoated) and bioactive coated (bioactive). Uncoated screws showed a significantly higher bone ingrowth value compared with the untreated screws in the OVX group (9.3%, P <0.005) and a significantly lower bone ingrowth value in the SHAM group (-11.0%, P <0.05). Furthermore, the bioactive pedicle screws had a significant lower bone ingrowth value than the untreated screws in the SHAM group (-12.1%, P <0.05). These results suggest that both tested surface treatments of pedicular screws may provide an advantage in terms of bone quality and osseointegration, when implanted in osteoporotic vertebrae.
AB - We investigate the anchorage of pedicle screws with different surface treatments in osteoporotic bone. Eight ewes were divided into two groups of four animals each: four sheep underwent bilateral ovariectomy (OVX Group), whereas the operation was simulated in the remaining group (SHAM Group). Eighteen months after the first operation, the Dynesys® System was fitted to the sheep using pedicle screws with three different surface treatments: untreated, rough blasted (uncoated) and bioactive coated (bioactive). Uncoated screws showed a significantly higher bone ingrowth value compared with the untreated screws in the OVX group (9.3%, P <0.005) and a significantly lower bone ingrowth value in the SHAM group (-11.0%, P <0.05). Furthermore, the bioactive pedicle screws had a significant lower bone ingrowth value than the untreated screws in the SHAM group (-12.1%, P <0.05). These results suggest that both tested surface treatments of pedicular screws may provide an advantage in terms of bone quality and osseointegration, when implanted in osteoporotic vertebrae.
KW - Osseointegration
KW - Osteoporosis
KW - Pedicle screws
KW - Surface treatment
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U2 - 10.1007/s00586-011-1831-5
DO - 10.1007/s00586-011-1831-5
M3 - Article
C2 - 21544593
AN - SCOPUS:83255194168
VL - 20
SP - 1289
EP - 1296
JO - European Spine Journal
JF - European Spine Journal
SN - 0940-6719
IS - 8
ER -