In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO

A. Facoetti, B. Vischioni, M. Ciocca, M. Ferrarini, Y. Furusawa, A. Mairani, Y. Matsumoto, A. Mirandola, S. Molinelli, A. Uzawa, Freixas G. Vilches, R. Orecchia

Research output: Contribution to journalArticle

Abstract

In this article, the in vivo study performed to evaluate the uniformity of biological doses within an hypothetical target volume and calculate the values of relative biological effectiveness (RBE) at different depths in the spread-out Bragg peak (SOBP) of the new CNAO (National Centre for Oncological Hadrontherapy) carbon beams is presented, in the framework of a typical radiobiological beam calibration procedure. The RBE values (relative to 60Co γ rays) of the CNAO active scanning carbon ion beams were determined using jejunal crypt regeneration in mice as biological system at the entrance, centre and distal end of a 6-cm SOBP. The RBE values calculated from the iso-effective doses to reduce crypt survival per circumference to 10, ranged from 1.52 at the middle of the SOBP to 1.75 at the distal position and are in agreement with those previously reported from other carbon ion facilities. In conclusion, this first set of in vivo experiments shows that the CNAO carbon beam is radiobiologically comparable with the NIRS (National Institute of Radiological Sciences, Chiba, Japan) and GSI (Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany) ones.

Original languageEnglish
Article numberncv145
Pages (from-to)379-382
Number of pages4
JournalRadiation Protection Dosimetry
Volume166
Issue number1-4
DOIs
Publication statusPublished - Sep 1 2015

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Relative Biological Effectiveness
Carbon
ion beams
Ions
carbon
dosage
circumferences
regeneration
Germany
entrances
Calibration
mice
Regeneration
Japan
rays
scanning
ions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

Cite this

Facoetti, A., Vischioni, B., Ciocca, M., Ferrarini, M., Furusawa, Y., Mairani, A., ... Orecchia, R. (2015). In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO. Radiation Protection Dosimetry, 166(1-4), 379-382. [ncv145]. https://doi.org/10.1093/rpd/ncv145

In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO. / Facoetti, A.; Vischioni, B.; Ciocca, M.; Ferrarini, M.; Furusawa, Y.; Mairani, A.; Matsumoto, Y.; Mirandola, A.; Molinelli, S.; Uzawa, A.; Vilches, Freixas G.; Orecchia, R.

In: Radiation Protection Dosimetry, Vol. 166, No. 1-4, ncv145, 01.09.2015, p. 379-382.

Research output: Contribution to journalArticle

Facoetti, A, Vischioni, B, Ciocca, M, Ferrarini, M, Furusawa, Y, Mairani, A, Matsumoto, Y, Mirandola, A, Molinelli, S, Uzawa, A, Vilches, FG & Orecchia, R 2015, 'In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO', Radiation Protection Dosimetry, vol. 166, no. 1-4, ncv145, pp. 379-382. https://doi.org/10.1093/rpd/ncv145
Facoetti A, Vischioni B, Ciocca M, Ferrarini M, Furusawa Y, Mairani A et al. In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO. Radiation Protection Dosimetry. 2015 Sep 1;166(1-4):379-382. ncv145. https://doi.org/10.1093/rpd/ncv145
Facoetti, A. ; Vischioni, B. ; Ciocca, M. ; Ferrarini, M. ; Furusawa, Y. ; Mairani, A. ; Matsumoto, Y. ; Mirandola, A. ; Molinelli, S. ; Uzawa, A. ; Vilches, Freixas G. ; Orecchia, R. / In Vivo radiobiological assessment of the new clinical carbon ion beams at CNAO. In: Radiation Protection Dosimetry. 2015 ; Vol. 166, No. 1-4. pp. 379-382.
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