In-vivo radiolabelled oxiracetam binding to rat brain

T. Mennini, C. Taddei, A. Cagnotto, F. Ponzio

Research output: Contribution to journalArticlepeer-review

Abstract

The in-vivo binding of [3H]oxiracetam has been studied in brain areas of rats examined 30 min after i.c.v. injection. Soluble radioactivity accounted for more than 90% of total radioactivity in all the structures considered and was not affected by co-injection with a 1000-fold excess of unlabelled oxiracetam. Both total and bound radioactivity showed a marked regional distribution, with highest concentrations in the septum, followed by the hippocampus; the cerebral cortex, striatum and cerebellum had the lower concentrations of radioactivity. Computer-assisted quantiative autoradiography with [14C]oxiracetam confirms these findings. Analysis of [3H]oxiracetam bound to membranes indicated that, after co-injection with a 1000-fold excess of unlabelled oxiracetam, there was a significant reduction of binding only in the septum, hippocampus and cerebral cortex. These results suggest that in those cerebral structures oxiracetam binds to saturable sites.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume42
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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