In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums

Gianmaria Fabrizio Ferrazzano, Tiziana Cantile, Marco Coda, Brunella Alcidi, Giancarla Sangianantoni, Aniello Ingenito, Michele di Stasio, Maria Grazia Volpe

Research output: Contribution to journalArticle

Abstract

Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.

Original languageEnglish
JournalMolecules
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2 2016
Externally publishedYes

Fingerprint

Mastication
Quercetin
Polyphenols
Kinetics
Molecules

Keywords

  • Journal Article

Cite this

Ferrazzano, G. F., Cantile, T., Coda, M., Alcidi, B., Sangianantoni, G., Ingenito, A., ... Volpe, M. G. (2016). In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums. Molecules, 21(8). https://doi.org/10.3390/molecules21081008

In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums. / Ferrazzano, Gianmaria Fabrizio; Cantile, Tiziana; Coda, Marco; Alcidi, Brunella; Sangianantoni, Giancarla; Ingenito, Aniello; di Stasio, Michele; Volpe, Maria Grazia.

In: Molecules, Vol. 21, No. 8, 02.08.2016.

Research output: Contribution to journalArticle

Ferrazzano, GF, Cantile, T, Coda, M, Alcidi, B, Sangianantoni, G, Ingenito, A, di Stasio, M & Volpe, MG 2016, 'In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums', Molecules, vol. 21, no. 8. https://doi.org/10.3390/molecules21081008
Ferrazzano GF, Cantile T, Coda M, Alcidi B, Sangianantoni G, Ingenito A et al. In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums. Molecules. 2016 Aug 2;21(8). https://doi.org/10.3390/molecules21081008
Ferrazzano, Gianmaria Fabrizio ; Cantile, Tiziana ; Coda, Marco ; Alcidi, Brunella ; Sangianantoni, Giancarla ; Ingenito, Aniello ; di Stasio, Michele ; Volpe, Maria Grazia. / In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums. In: Molecules. 2016 ; Vol. 21, No. 8.
@article{bee5a66984124910a844beb9c155b3f5,
title = "In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums",
abstract = "Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.",
keywords = "Journal Article",
author = "Ferrazzano, {Gianmaria Fabrizio} and Tiziana Cantile and Marco Coda and Brunella Alcidi and Giancarla Sangianantoni and Aniello Ingenito and {di Stasio}, Michele and Volpe, {Maria Grazia}",
year = "2016",
month = "8",
day = "2",
doi = "10.3390/molecules21081008",
language = "English",
volume = "21",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums

AU - Ferrazzano, Gianmaria Fabrizio

AU - Cantile, Tiziana

AU - Coda, Marco

AU - Alcidi, Brunella

AU - Sangianantoni, Giancarla

AU - Ingenito, Aniello

AU - di Stasio, Michele

AU - Volpe, Maria Grazia

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.

AB - Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.

KW - Journal Article

U2 - 10.3390/molecules21081008

DO - 10.3390/molecules21081008

M3 - Article

C2 - 27490529

VL - 21

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 8

ER -