In vivo spectrophotometric evaluation of neoplastic and non-neoplastic skin pigmented lesions--I. Reflectance measurements.

R. Marchesini, M. Brambilla, C. Clemente, M. Maniezzo, A. E. Sichirollo, A. Testori, D. R. Venturoli, N. Cascinelli

Research output: Contribution to journalArticle

Abstract

Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectance spectra of the different lesions manifest dissimilar patterns, particularly in the near IR region. Comparison of reflectance of nevi with that of malignant melanomas results in a highly significant difference (P less than 10(-6)) between the two samples. Though interpretation of the spectra remains difficult as a result of the complexity of the optical processes of scattering and absorption, our results suggest that a detailed analysis of the reflectance spectrum may give clinically useful information, and could be utilized as an aid in clinical diagnosis of cutaneous pigmented lesions, especially where malignant melanoma is concerned.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalPhotochemistry and Photobiology
Volume53
Issue number1
Publication statusPublished - Jan 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Fingerprint Dive into the research topics of 'In vivo spectrophotometric evaluation of neoplastic and non-neoplastic skin pigmented lesions--I. Reflectance measurements.'. Together they form a unique fingerprint.

  • Cite this

    Marchesini, R., Brambilla, M., Clemente, C., Maniezzo, M., Sichirollo, A. E., Testori, A., Venturoli, D. R., & Cascinelli, N. (1991). In vivo spectrophotometric evaluation of neoplastic and non-neoplastic skin pigmented lesions--I. Reflectance measurements. Photochemistry and Photobiology, 53(1), 77-84.