Abstract
Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 203-214 |
| Number of pages | 12 |
| Journal | Pharmacological Research Communications |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1977 |
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ASJC Scopus subject areas
- Pharmacology
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In vivo studies of catechol-o-methyl transferase activity following intoxication with ethanol, L-dopa and dopamine-derived alkaloids. / Giovine, A.; Renis, M.; Bertolino, A.
In: Pharmacological Research Communications, Vol. 9, No. 2, 1977, p. 203-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo studies of catechol-o-methyl transferase activity following intoxication with ethanol, L-dopa and dopamine-derived alkaloids
AU - Giovine, A.
AU - Renis, M.
AU - Bertolino, A.
PY - 1977
Y1 - 1977
N2 - Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
AB - Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
UR - http://www.scopus.com/inward/record.url?scp=0017335733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017335733&partnerID=8YFLogxK
U2 - 10.1016/S0031-6989(77)80024-6
DO - 10.1016/S0031-6989(77)80024-6
M3 - Article
C2 - 559308
AN - SCOPUS:0017335733
VL - 9
SP - 203
EP - 214
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 2
ER -