TY - JOUR
T1 - In vivo studies of catechol-o-methyl transferase activity following intoxication with ethanol, L-dopa and dopamine-derived alkaloids
AU - Giovine, A.
AU - Renis, M.
AU - Bertolino, A.
PY - 1977
Y1 - 1977
N2 - Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
AB - Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
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U2 - 10.1016/S0031-6989(77)80024-6
DO - 10.1016/S0031-6989(77)80024-6
M3 - Article
C2 - 559308
AN - SCOPUS:0017335733
VL - 9
SP - 203
EP - 214
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 2
ER -