Only 20% inhibition in rat brain catechol-O-methyl transferase (COMT) activity was observed after chronic treatment with a 20% ethanol-water solution for 180 days. When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%. Inhibition was 45% in experiments in which rats treated acutely with ethanol 5g/Kg in a unit dose were administered with L-dopa 60 mg/Kg. As regard tetrahydropapaveroline (THP) and salsolinol, 8 and 60 mg/Kg cause a slight but significant inhibitory effect for up two hours following treatment.
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