In vivo studies on genotoxicity of a soil fumigant, dazomet

Marco Peluso, Claudia Bolognesi, Armelle Munnia, Eleonora Landini, Silvia Parodi

Research output: Contribution to journalArticlepeer-review

Abstract

Dazomet is a soil fumigant effective against germinating weed seeds, nematodes, soil fungi, and soil insects. Dazomet is primarily used for preplanting control in tobacco and forest nursery crops and is now marketed for a wider range of open field and greenhouse crops (e.g., vegetables, fruits, ornamental plants, lawns, and turfs). Swiss CD1 male and female mice were intraperitoneally treated with dazomet in order to evaluate its potential genotoxicity. DNA damage activity, namely, DNA single-strand breaks, DNA adducts, and increased micronuclei frequency due to treatment with the soil fumigant was observed in the experimental animals. Dose- dependent DNA adduct formation was detected in the liver, kidneys, and lungs of mice. DNA adduct levels in these three organs were 6.0 ± 0.4 (SD), 4.8 ± 0.1 (SD), and 2.2 ± 0.4 (SD) adducts/108 nucleotides, respectively, at the highest dose of the soil fumigant tested (90 mg/kg). No adduct formation was observed in control mice. A significant cant increase in DNA single-strand breaks was detected in the liver and kidneys of mice treated with 100 mg/kg of dazomet (P <0.05). A significant increase in micronuclei frequency was observed in the bone marrow of mice treated with 100 mg/kg of dazomet (P <0.05).

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalEnvironmental and Molecular Mutagenesis
Volume32
Issue number2
DOIs
Publication statusPublished - 1998

Keywords

  • Dazomet
  • DNA damage
  • Mouse
  • Soil fumigant

ASJC Scopus subject areas

  • Genetics
  • Environmental Science(all)
  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Genetics(clinical)
  • Toxicology

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