In vivo studies on the enhancement of serotonin reuptake by tianeptine

Maria Grazia De Simoni, Ada De Luigi, Angelo Clavenna, Alfredo Manfridi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The present study investigates the in vivo effects of the serotonin uptake enhancer tianeptine. The serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA) was measured by in vivo voltammetry and carbon fiber electrodes chronically implanted in different brain areas of freely moving rats. Tianeptine (10 mg/kg i.p.) increased extracellular 5-HIAA in the hippocampus and hypothalamus. The interaction between tianeptine and drugs known to interfere with the uptake or release of serotonin (sertraline, buspirone, d-norfenfluramine) was then studied and, to ascertain the in vivo pharmacological relevance of tianeptine's effects, its ability to reduce the serotoninergic syndrome was evaluated. Both the biochemical and behavioral data indicate that in vivo tianeptine's effects on the serotoninergic system are likely to be due to serotonin uptake enhancement.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalBrain Research
Volume574
Issue number1-2
DOIs
Publication statusPublished - Mar 6 1992

Fingerprint

tianeptine
Serotonin
Norfenfluramine
Buspirone
Sertraline
Implanted Electrodes
Acids
Hypothalamus
Hippocampus
Pharmacology

Keywords

  • 5-Hydroxyindolacetic acid
  • Serotonin
  • Tianeptine
  • Voltammetry, in vivo

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

In vivo studies on the enhancement of serotonin reuptake by tianeptine. / De Simoni, Maria Grazia; De Luigi, Ada; Clavenna, Angelo; Manfridi, Alfredo.

In: Brain Research, Vol. 574, No. 1-2, 06.03.1992, p. 93-97.

Research output: Contribution to journalArticle

De Simoni, Maria Grazia ; De Luigi, Ada ; Clavenna, Angelo ; Manfridi, Alfredo. / In vivo studies on the enhancement of serotonin reuptake by tianeptine. In: Brain Research. 1992 ; Vol. 574, No. 1-2. pp. 93-97.
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