In vivo study of polyurethane-coated Gianturco-Rosch biliary Z-stents

Aldo Severini, Sara Mantero, Maria Cristina Tanzi, Alberto Cigada, Flaminio Addis, Guido Cozzi, Monica Salvetti, Salvatore Andreola, Antonella Motta, Enrico Regalia, Andrea Pulvirenti, Enrico De Pedri, Roberto Doci

Research output: Contribution to journalArticle

Abstract

Purpose: Prototypes of Gianturco-Rosch Z-stents coated with polycarbonate urethane (PCU) were placed in the biliary tree of pigs, in order to test their biomechanical behavior, stability, and biocompatibility. Methods: The stents were surgically implanted in the common bile duct of three pairs of pigs, which were killed after 1, 3, and 6 months respectively. Explanted livers from pigs of the same race, age, and size were used to provide comparative data. The bile ducts were radiologically and histopathologically examined; the stents were processed and examined by scanning electron microscopy. Results: No complications occurred and the animals showed a normal weight gain. The main bile duct appeared radiologically and macroscopically dilated, but the stents proved to be in place. Histologically, the bile duct epithelium was destroyed, but neither hyperplastic nor inflammatory fibrotic reactions of the wall were evident. Both the metallic structure and the polymeric coating of the stents were intact. A layer of organic material with a maximum thickness of approximately 3 μm was evident on the inner surface of the stents. Conclusion: The present in vivo study demonstrates the biocompatibility, efficacy, and stability of PCU-coated Gianturco-Rosch stents in the biliary environment.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
JournalCardioVascular and Interventional Radiology
Volume22
Issue number6
DOIs
Publication statusPublished - Nov 1999

Keywords

  • Bile drainage
  • Biliary prostheses
  • Metallic stents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Severini, A., Mantero, S., Tanzi, M. C., Cigada, A., Addis, F., Cozzi, G., Salvetti, M., Andreola, S., Motta, A., Regalia, E., Pulvirenti, A., De Pedri, E., & Doci, R. (1999). In vivo study of polyurethane-coated Gianturco-Rosch biliary Z-stents. CardioVascular and Interventional Radiology, 22(6), 510-514. https://doi.org/10.1007/s002709900441