TY - JOUR
T1 - In vivo tracking of stem cell by nanotechnologies
T2 - Future prospects for mouse to human translation
AU - Villa, Chiara
AU - Erratico, Silvia
AU - Razini, Paola
AU - Farini, Andrea
AU - Meregalli, Mirella
AU - Belicchi, Marzia
AU - Torrente, Yvan
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. Dynamic determination of stem cell migration and distribution in real time is essential for optimizing treatments in preclinical models and designing clinical protocols. Recent developments in the use of nanotechnologies have contributed to advance of the high-resolution in vivo imaging methods, including the positron emission tomography, the single-photon emission computed tomography, the magnetic resonance imaging, and microcomputed tomography. This review examines the use of nanotechnologies for stem cell tracking, the many contrast agents, and detectors that have been proposed and suggest future directions for mouse to human translation of these techniques, for both therapeutic and diagnostic purposes.
AB - Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. Dynamic determination of stem cell migration and distribution in real time is essential for optimizing treatments in preclinical models and designing clinical protocols. Recent developments in the use of nanotechnologies have contributed to advance of the high-resolution in vivo imaging methods, including the positron emission tomography, the single-photon emission computed tomography, the magnetic resonance imaging, and microcomputed tomography. This review examines the use of nanotechnologies for stem cell tracking, the many contrast agents, and detectors that have been proposed and suggest future directions for mouse to human translation of these techniques, for both therapeutic and diagnostic purposes.
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U2 - 10.1089/ten.teb.2010.0362
DO - 10.1089/ten.teb.2010.0362
M3 - Article
C2 - 20846051
AN - SCOPUS:79251552572
VL - 17
SP - 1
EP - 11
JO - Tissue Engineering - Part B: Reviews
JF - Tissue Engineering - Part B: Reviews
SN - 1937-3368
IS - 1
ER -