In vivo treatment with GM1 prevents the rapid decay of ATPase activities and mitochondrial damage in hippocampal slices

Roberto Bianchi, Damir Janigro, Fabrizio Milan, Giovanni Giudici, Alfredo Gorio

Research output: Contribution to journalArticle

Abstract

Slices from rat CA3 hippocampal area show a 30% decrement in ATPase activity after 35 min of 'in vitro' incubation. Such a drop is accompanied by an alteration of mitochondrial ultrastructure. However, if rats are treated daily with GM1 ganglioside (10 mg/kg during 3 days) both phenomena are fully prevented. These results would suggest a protective effect of gangliosides onto membrane structures under stress conditions.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalBrain Research
Volume364
Issue number2
DOIs
Publication statusPublished - Feb 5 1986

Keywords

  • ganglioside
  • hippocampus
  • mitochondrion
  • Na,K-ATPase

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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