In vivo two-photon imaging of climbing fibers plasticity after laser axotomy

A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, V. De Paola, P. Strata, F. S. Pavone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the adult nervous system, different neuronal classes show different regenerative behavior. Although previous studies demonstrated that olivocerebellar fibers are capable of axonal regeneration in a suitable environment as a response to injury, we have hitherto no details about the real dynamics of fiber regeneration. We set up a model of singularly axotomized climbing fibers (CF) to investigate their reparative properties in the adult central nervous system (CNS) in vivo. Here we describe the approach followed to characterize the reactive plasticity after injury.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8804
DOIs
Publication statusPublished - 2013
EventNeurophotonics - Munich, Germany
Duration: May 12 2013May 14 2013

Other

OtherNeurophotonics
CountryGermany
CityMunich
Period5/12/135/14/13

Keywords

  • cerebellum
  • laser axotomy
  • live imaging
  • mice
  • nanosurgery
  • plasticity
  • Two-photon imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'In vivo two-photon imaging of climbing fibers plasticity after laser axotomy'. Together they form a unique fingerprint.

  • Cite this

    Allegra Mascaro, A. L., Cesare, P., Sacconi, L., Grasselli, G., Mandolesi, G., Maco, B., Knott, G. W., De Paola, V., Strata, P., & Pavone, F. S. (2013). In vivo two-photon imaging of climbing fibers plasticity after laser axotomy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8804). [880407] https://doi.org/10.1117/12.2032180