In vivo two-photon imaging of climbing fibers plasticity after laser axotomy

A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, V. De Paola, P. Strata, F. S. Pavone

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In the adult nervous system, different neuronal classes show different regenerative behavior. Although previous studies demonstrated that olivocerebellar fibers are capable of axonal regeneration in a suitable environment as a response to injury, we have hitherto no details about the real dynamics of fiber regeneration. We set up a model of singularly axotomized climbing fibers (CF) to investigate their reparative properties in the adult central nervous system (CNS) in vivo. Here we describe the approach followed to characterize the reactive plasticity after injury

Original languageEnglish
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)9780819496461
Publication statusPublished - 2013
EventEuropean Conference on Biomedical Optics, ECBO 2013 - Munich, Germany
Duration: May 12 2013May 16 2013


OtherEuropean Conference on Biomedical Optics, ECBO 2013


  • Cerebellum
  • Laser axotomy
  • Live imaging
  • Mice
  • Nanosurgery
  • Plasticity
  • Two-photon imaging

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics


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