Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect

Wan Yun Ma, Ida Ortalli, Giuseppe Pedrazzi, Silvia Vaccari, Carmelo Carlo-Stella

Research output: Contribution to journalArticle

Abstract

Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalAnticancer Research
Volume18
Issue number1 A
Publication statusPublished - Jan 1998

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Keywords

  • Bone marrow
  • Inactivation
  • K652
  • Mossbauer effect

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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