Inactivation of DNA repair - Prospects for boosting cancer immune surveillance

Research output: Contribution to journalReview article

Abstract

The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered. Notably, although the emergence of new mutations fosters drug resistance, new variants can nevertheless become novel antigens that promote immune surveillance and even restrict cancer growth.

Original languageEnglish
Article number91
JournalGenome Medicine
Volume10
Issue number1
DOIs
Publication statusPublished - Nov 28 2018

Keywords

  • Immune surveillance
  • Mismatch repair
  • MMR
  • Mutational burden
  • Neoantigen
  • Tumor
  • Tumor evolution

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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