Inactivation of DNA repair - Prospects for boosting cancer immune surveillance

Anna Truini; Giovanni Germano; Alberto Bardelli

doi:10.1186/s13073-018-0603-9

Inactivation of DNA repair - Prospects for boosting cancer immune surveillance

Anna Truini, Giovanni Germano, Alberto Bardelli

Istituto Oncologico Candiolo

Research output: Contribution to journal › Review article › peer-review

Abstract

The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered. Notably, although the emergence of new mutations fosters drug resistance, new variants can nevertheless become novel antigens that promote immune surveillance and even restrict cancer growth.

Original language	English
Article number	91
Journal	Genome Medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13073-018-0603-9
Publication status	Published - Nov 28 2018

Keywords

Immune surveillance
Mismatch repair
MMR
Mutational burden
Neoantigen
Tumor
Tumor evolution

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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KW - Mutational burden

KW - Neoantigen

KW - Tumor

KW - Tumor evolution

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Inactivation of DNA repair - Prospects for boosting cancer immune surveillance

Abstract

Keywords

ASJC Scopus subject areas

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