Inactivation of DNA repair - Prospects for boosting cancer immune surveillance

Anna Truini, Giovanni Germano, Alberto Bardelli

Research output: Contribution to journalReview articlepeer-review


The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered. Notably, although the emergence of new mutations fosters drug resistance, new variants can nevertheless become novel antigens that promote immune surveillance and even restrict cancer growth.

Original languageEnglish
Article number91
JournalGenome Medicine
Issue number1
Publication statusPublished - Nov 28 2018


  • Immune surveillance
  • Mismatch repair
  • MMR
  • Mutational burden
  • Neoantigen
  • Tumor
  • Tumor evolution

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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