Inactive disease and remission in childhood-onset systemic lupus erythematosus.

Rina Mina, Marisa S. Klein-Gitelman, Angelo Ravelli, Michael W. Beresford, Tadej Avcin, Graciela Espada, B. Anne Eberhard, Laura E. Schanberg, Kathleen M. O'Neil, Clovis A. Silva, Gloria C. Higgins, Karen Onel, Nora G. Singer, Emily von Scheven, Lisa F. Imundo, Shannen Nelson, Edward H. Giannini, Hermine I. Brunner

Research output: Contribution to journalArticlepeer-review


To define inactive disease (ID) and clinical remission (CR) and to delineate variables that can be used to measure ID/CR in childhood-onset systemic lupus erythematosus (cSLE). Delphi questionnaires were sent to an international group of pediatric rheumatologists. Respondents provided information about variables to be used in future algorithms to measure ID/CR. The usefulness of these variables was assessed in 35 children with ID and 31 children with minimally active lupus (MAL). While ID reflects cSLE status at a specific point in time, CR requires the presence of ID for >6 months and considers treatment. There was consensus that patients in ID/CR can have 0.85). Disease activity scores with or without the physician global assessment of disease activity and patient symptoms were well suited to differentiate children with ID from those with MAL. Consensus has been reached on common definitions of ID/CR with cSLE and relevant patient characteristics with ID/CR. Further studies must assess the usefulness of the data-driven candidate criteria for ID in cSLE.

Original languageEnglish
Pages (from-to)683-693
Number of pages11
JournalArthritis Care and Research
Issue number5
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Medicine(all)


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