Abstract
Unidimensional Response Evaluation Criteria in Solid Tumor (RECIST) has been recently proposed in the attempt to simplify the standardized bidimensional World Health Organization (WHO) criteria. The complete accord between these two measurement systems was established in a large comparative study [J. Natl. Cancer Inst. 92(3) (2000) 205] that demonstrated the validity and the good performance of RECIST criteria. We report four cases of inadequacy of RECIST criteria in the evaluation of response to chemotherapy in patients with malignant pleural mesothelioma. These four patients were enrolled in two consecutive multicenter phase II clinical trials investigating the activity of a novel chemotherapy regimen in advanced pleural mesothelioma. They were judged as having an objective response to chemotherapy according to WHO criteria. Reassessed according to both methods, we found that results obtained with RECIST criteria do not correspond to WHO underestimating response to chemotherapy. Our data raise doubts about the applicability of unidimensional RECIST response criteria to mesothelioma and, possibly, to any tumor involving the chest wall.
| Original language | English |
|---|---|
| Pages (from-to) | 71-74 |
| Number of pages | 4 |
| Journal | Lung Cancer |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2004 |
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Keywords
- Chemotherapy
- CT
- Mesothelioma
- RECIST
ASJC Scopus subject areas
- Oncology
Cite this
Inadequacy of the new Response Evaluation Criteria in Solid Tumors (RECIST) in patients with malignant pleural mesothelioma : Report of four cases. / Monetti, F.; Casanova, S.; Grasso, A.; Cafferata, M. A.; Ardizzoni, A.; Neumaier, C. E.
In: Lung Cancer, Vol. 43, No. 1, 01.2004, p. 71-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inadequacy of the new Response Evaluation Criteria in Solid Tumors (RECIST) in patients with malignant pleural mesothelioma
T2 - Report of four cases
AU - Monetti, F.
AU - Casanova, S.
AU - Grasso, A.
AU - Cafferata, M. A.
AU - Ardizzoni, A.
AU - Neumaier, C. E.
PY - 2004/1
Y1 - 2004/1
N2 - Unidimensional Response Evaluation Criteria in Solid Tumor (RECIST) has been recently proposed in the attempt to simplify the standardized bidimensional World Health Organization (WHO) criteria. The complete accord between these two measurement systems was established in a large comparative study [J. Natl. Cancer Inst. 92(3) (2000) 205] that demonstrated the validity and the good performance of RECIST criteria. We report four cases of inadequacy of RECIST criteria in the evaluation of response to chemotherapy in patients with malignant pleural mesothelioma. These four patients were enrolled in two consecutive multicenter phase II clinical trials investigating the activity of a novel chemotherapy regimen in advanced pleural mesothelioma. They were judged as having an objective response to chemotherapy according to WHO criteria. Reassessed according to both methods, we found that results obtained with RECIST criteria do not correspond to WHO underestimating response to chemotherapy. Our data raise doubts about the applicability of unidimensional RECIST response criteria to mesothelioma and, possibly, to any tumor involving the chest wall.
AB - Unidimensional Response Evaluation Criteria in Solid Tumor (RECIST) has been recently proposed in the attempt to simplify the standardized bidimensional World Health Organization (WHO) criteria. The complete accord between these two measurement systems was established in a large comparative study [J. Natl. Cancer Inst. 92(3) (2000) 205] that demonstrated the validity and the good performance of RECIST criteria. We report four cases of inadequacy of RECIST criteria in the evaluation of response to chemotherapy in patients with malignant pleural mesothelioma. These four patients were enrolled in two consecutive multicenter phase II clinical trials investigating the activity of a novel chemotherapy regimen in advanced pleural mesothelioma. They were judged as having an objective response to chemotherapy according to WHO criteria. Reassessed according to both methods, we found that results obtained with RECIST criteria do not correspond to WHO underestimating response to chemotherapy. Our data raise doubts about the applicability of unidimensional RECIST response criteria to mesothelioma and, possibly, to any tumor involving the chest wall.
KW - Chemotherapy
KW - CT
KW - Mesothelioma
KW - RECIST
UR - http://www.scopus.com/inward/record.url?scp=0346456852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346456852&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2003.07.005
DO - 10.1016/j.lungcan.2003.07.005
M3 - Article
C2 - 14698539
AN - SCOPUS:0346456852
VL - 43
SP - 71
EP - 74
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 1
ER -