Inadequate erythropoietin response to anemia

definition and clinical relevance

G. Barosi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The development of a specific and sensitive immunoassay for the measurement of serum erythropoietin (s-Epo) allows to improve our understanding of the model of in vivo regulation of erythropoiesis. In most anemias, circulating hemoglobin level determines Epo production which in turn stimulates erythropoietic activity. The disruption of the expected feedback mechanism of Epo production leads to an inadequately low s-Epo. The definition of inadequate Epo response to anemia relies on the documentation of a downregulated dependence of s-Epo on Hb with respect to the same dependence in patients with a physiologically regulated erythropoiesis. Literature reports a wide range of so called adequate s-Epo response to anemia and a number of criteria for judging on the adequateness of s-Epo at a certain degree of anemia. The O/P (observed/predicted) ratio allows categorization of each individual patient. The clinical syndromes in which an inadequate Epo response has been reported are numerous and the mechanisms of defective Epo production are different. A number of evidences clearly point to a relation between responsiveness to r-Hu-Epo and inadequate Epo response. This inequivocabily confirms the role inadequate Epo response plays in the pathogenesis of anemia.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalAnnals of Hematology
Volume68
Issue number5
DOIs
Publication statusPublished - May 1994

Fingerprint

Erythropoietin
Anemia
Serum
Erythropoiesis
Immunoassay
Documentation
Hemoglobins
Down-Regulation

Keywords

  • Erythropoiesis
  • Erythropoietin
  • Inadequate erythropoietin production

ASJC Scopus subject areas

  • Hematology

Cite this

Inadequate erythropoietin response to anemia : definition and clinical relevance. / Barosi, G.

In: Annals of Hematology, Vol. 68, No. 5, 05.1994, p. 215-223.

Research output: Contribution to journalArticle

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