Inappropriate left ventricular mass in children and young adults with chronic renal insufficiency

Francesca Raimondi, Marcello Chinali, Daniela Girfoglio, Margherita Benincasa, Luciano Pasquini, Francesco Emma, Giovanni Simone, Maria Chiara Matteucci

Research output: Contribution to journalArticlepeer-review

Abstract

Increased left ventricular (LV) mass (M) in children with chronic renal insufficiency (CRI) might represent an adaptive mechanism to compensate for increased workload. We hypothesized that in children with CRI, pre-dialysis, values of left ventricular mass (LVM) exceed compensatory values for individual cardiac load. Complete anthropometric characteristics, biochemical profile and echocardiograms were obtained for 33 children with CRI, pre-dialysis (age 1-23 years, mean 12.2±5.0 years), and 33 age- and gender-matched healthy controls. LV dimensions, wall thicknesses and volume were measured. Endocardial and midwall shortening, ejection fraction, LVM, LVM index, relative wall thickness, circumferential wall stress and excess LVM (as ratio of observed LVM to value predicted from body size, gender and cardiac workload) were analysed. Patients with CRI showed higher values of LVM index, resulting in higher prevalence of LV hypertrophy (36.3% vs 9%, P

Original languageEnglish
Pages (from-to)2015-2022
Number of pages8
JournalPediatric Nephrology
Volume24
Issue number10
DOIs
Publication statusPublished - 2009

Keywords

  • Cardiac workload
  • Chronic renal insufficiency
  • Inappropriate left ventricular (LV) mass
  • Left ventricular hypertrophy
  • Myocardial performance

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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