Abstract
A 36-year-old female, presenting with jaundice, developed acute liver failure requiring orthotopic liver transplantation. On admission, none of the known causative factors for acute hepatitis, including use of drugs, were found to be present. Several days after hospitalization, the patient admitted taking therapy prescribed by a "non-traditional" physician, that she had been using for several years due to overweight and which had recently been modified with the introduction of pemoline. A considerable body of evidence exists in the medical literature showing that pemoline, which is a central nervous system stimulant, has variable hepatotoxic effects, ranging from a mild transient increase of serum transaminases to liver failure, including some lethal cases.
| Original language | English |
|---|---|
| Pages (from-to) | 447-451 |
| Number of pages | 5 |
| Journal | Digestive and Liver Disease |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Acute liver failure
- Hepatotoxicity
- Liver transplantation
- Pemoline
ASJC Scopus subject areas
- Gastroenterology
Cite this
Inappropriate pemoline therapy leading to acute liver failure and liver transplantation. / Abbiati, C.; Vecchi, M.; Rossi, G.; Donato, M. F.; De Franchis, R.
In: Digestive and Liver Disease, Vol. 34, No. 6, 2002, p. 447-451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inappropriate pemoline therapy leading to acute liver failure and liver transplantation
AU - Abbiati, C.
AU - Vecchi, M.
AU - Rossi, G.
AU - Donato, M. F.
AU - De Franchis, R.
PY - 2002
Y1 - 2002
N2 - A 36-year-old female, presenting with jaundice, developed acute liver failure requiring orthotopic liver transplantation. On admission, none of the known causative factors for acute hepatitis, including use of drugs, were found to be present. Several days after hospitalization, the patient admitted taking therapy prescribed by a "non-traditional" physician, that she had been using for several years due to overweight and which had recently been modified with the introduction of pemoline. A considerable body of evidence exists in the medical literature showing that pemoline, which is a central nervous system stimulant, has variable hepatotoxic effects, ranging from a mild transient increase of serum transaminases to liver failure, including some lethal cases.
AB - A 36-year-old female, presenting with jaundice, developed acute liver failure requiring orthotopic liver transplantation. On admission, none of the known causative factors for acute hepatitis, including use of drugs, were found to be present. Several days after hospitalization, the patient admitted taking therapy prescribed by a "non-traditional" physician, that she had been using for several years due to overweight and which had recently been modified with the introduction of pemoline. A considerable body of evidence exists in the medical literature showing that pemoline, which is a central nervous system stimulant, has variable hepatotoxic effects, ranging from a mild transient increase of serum transaminases to liver failure, including some lethal cases.
KW - Acute liver failure
KW - Hepatotoxicity
KW - Liver transplantation
KW - Pemoline
UR - http://www.scopus.com/inward/record.url?scp=0036087118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036087118&partnerID=8YFLogxK
U2 - 10.1016/S1590-8658(02)80043-3
DO - 10.1016/S1590-8658(02)80043-3
M3 - Article
C2 - 12132793
AN - SCOPUS:0036087118
VL - 34
SP - 447
EP - 451
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 6
ER -