Incidence and clinical features of acute inflammatory polyradiculoneuropathy in Lombardy, Italy, 1996

Graziella Bogliun, Ettore Beghi

Research output: Contribution to journalArticlepeer-review


Objective - To assess the annual incidence of typical Guillain-Barré syndrome (GBS) and its main variants (atypical GBS) in a well-defined population from a large area. Material and methods - A population-based prospective survey of GBS was undertaken during the calendar year 1996 in Lombardy, Italy (population 8,891,652). Typical and atypical GBS was diagnosed using the National Institutes of Neurological and Communicative Disorders and Stroke (NINCDS) and Ropper criteria. Eligible cases were hospital inpatients traced through a regional registry, the hospital discharge diagnoses, and an ongoing case-control study. Diagnostic and demographic findings were collected for each case. Complete clinical and laboratory features were available for 80% of cases. Results - A total of 138 patients (males 74; females 64) aged 2-91 years fulfilled the diagnostic criteria for typical GBS (128) or atypical GBS (10). GBS variants included Miller-Fisher syndrome (four cases), cranial polyneuritis (three cases), pure motor GBS (two cases), and sensory loss with areflexia (one case). The crude annual incidence of GBS was 1.55 per 100,000 (typical GBS 1.43; atypical GBS 0.11; male 1.67; female 1.43; age

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalActa Neurologica Scandinavica
Issue number2
Publication statusPublished - Aug 2004


  • Epidemiology
  • Guillain-Barré syndrome
  • Polyradiculoneuritis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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