Abstract
Kaposi's sarcoma (KS) can be a complication of solid organ transplantation, but with an important incidence rate variability in different geographical areas. Here we analyzed the incidence rate, timing and clinical correlates of KS, in a cohort of Italian solid organ transplant recipients from four distinct transplantation centers. A total of 1721 renal, heart and liver transplant recipients were recruited between 1997 and 2004. KS was diagnosed in 40 patients, after a median follow up of 1 year (range 0.8-5.1). Visceral involvement was detected in 7/40 patients. Incidence rate of KS in the whole population was 2.3 cases per 1000 individuals per year. The standardized incidence rate (SIR) for KS in renal transplant recipients was 149.9 (95% CI 103.0-212.0), with the excess risk greater among women (SIR 316.0) than among men (SIR 133.6). In a Cox proportional hazard regression model, age at transplantation equal or older than 30 years and only combined immunosuppressive therapy with mycophenolate mofetil + cyclosporine + prednisolone were independently associated with KS. Italian organ transplant recipients have an increased risk (about 100 times greater) for KS compared to the general population, especially during the first two years after transplantation. Age older than 30 years at transplantation and a more aggressive immunosuppressive regimen were both independent risk factors for the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 553-557 |
| Number of pages | 5 |
| Journal | European Journal of Dermatology |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 2006 |
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Keywords
- Immunosuppression
- Kaposi's sarcoma
- Risk factors
- Transplant recipients
ASJC Scopus subject areas
- Dermatology
Cite this
Incidence and clinical predictors of Kaposi's sarcoma among 1721 Italian solid organ transplant recipients : A multicenter study. / Tessari, Gianpaolo; Naldi, Luigi; Boschiero, Luigino; Cordiano, Claudio; Piaserico, Stefano; Fortina, Anna Belloni; Cerimele, Decio; La Parola, Ilaria Lesnoni; Capuano, Maria; Gotti, Eliana; Ruggenenti, Piero; Sassi, Fabrizia; Remuzzi, Giuseppe; Girolomoni, Giampiero.
In: European Journal of Dermatology, Vol. 16, No. 5, 09.2006, p. 553-557.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence and clinical predictors of Kaposi's sarcoma among 1721 Italian solid organ transplant recipients
T2 - A multicenter study
AU - Tessari, Gianpaolo
AU - Naldi, Luigi
AU - Boschiero, Luigino
AU - Cordiano, Claudio
AU - Piaserico, Stefano
AU - Fortina, Anna Belloni
AU - Cerimele, Decio
AU - La Parola, Ilaria Lesnoni
AU - Capuano, Maria
AU - Gotti, Eliana
AU - Ruggenenti, Piero
AU - Sassi, Fabrizia
AU - Remuzzi, Giuseppe
AU - Girolomoni, Giampiero
PY - 2006/9
Y1 - 2006/9
N2 - Kaposi's sarcoma (KS) can be a complication of solid organ transplantation, but with an important incidence rate variability in different geographical areas. Here we analyzed the incidence rate, timing and clinical correlates of KS, in a cohort of Italian solid organ transplant recipients from four distinct transplantation centers. A total of 1721 renal, heart and liver transplant recipients were recruited between 1997 and 2004. KS was diagnosed in 40 patients, after a median follow up of 1 year (range 0.8-5.1). Visceral involvement was detected in 7/40 patients. Incidence rate of KS in the whole population was 2.3 cases per 1000 individuals per year. The standardized incidence rate (SIR) for KS in renal transplant recipients was 149.9 (95% CI 103.0-212.0), with the excess risk greater among women (SIR 316.0) than among men (SIR 133.6). In a Cox proportional hazard regression model, age at transplantation equal or older than 30 years and only combined immunosuppressive therapy with mycophenolate mofetil + cyclosporine + prednisolone were independently associated with KS. Italian organ transplant recipients have an increased risk (about 100 times greater) for KS compared to the general population, especially during the first two years after transplantation. Age older than 30 years at transplantation and a more aggressive immunosuppressive regimen were both independent risk factors for the disease.
AB - Kaposi's sarcoma (KS) can be a complication of solid organ transplantation, but with an important incidence rate variability in different geographical areas. Here we analyzed the incidence rate, timing and clinical correlates of KS, in a cohort of Italian solid organ transplant recipients from four distinct transplantation centers. A total of 1721 renal, heart and liver transplant recipients were recruited between 1997 and 2004. KS was diagnosed in 40 patients, after a median follow up of 1 year (range 0.8-5.1). Visceral involvement was detected in 7/40 patients. Incidence rate of KS in the whole population was 2.3 cases per 1000 individuals per year. The standardized incidence rate (SIR) for KS in renal transplant recipients was 149.9 (95% CI 103.0-212.0), with the excess risk greater among women (SIR 316.0) than among men (SIR 133.6). In a Cox proportional hazard regression model, age at transplantation equal or older than 30 years and only combined immunosuppressive therapy with mycophenolate mofetil + cyclosporine + prednisolone were independently associated with KS. Italian organ transplant recipients have an increased risk (about 100 times greater) for KS compared to the general population, especially during the first two years after transplantation. Age older than 30 years at transplantation and a more aggressive immunosuppressive regimen were both independent risk factors for the disease.
KW - Immunosuppression
KW - Kaposi's sarcoma
KW - Risk factors
KW - Transplant recipients
UR - http://www.scopus.com/inward/record.url?scp=33845335203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845335203&partnerID=8YFLogxK
U2 - 10.1684/ejd.2006.0029
DO - 10.1684/ejd.2006.0029
M3 - Article
C2 - 17101478
AN - SCOPUS:33845335203
VL - 16
SP - 553
EP - 557
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 5
ER -