Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study

Claudia Mucciarini, Giulio Rossi, Federica Bertolini, Riccardo Valli, Claudia Cirilli, Ivan Rashid, Luigi Marcheselli, Gabriele Luppi, Massimo Federico

Research output: Contribution to journalArticle

Abstract

Background: Although the diagnostic criteria and pathogenesis of gastrointestinal stromal tumors (GIST) have recently been elucidated, knowledge of the epidemiology of this malignancy is still limited. This study examined the incidence of GIST in the province of Modena, including pathologic features and clinical outcome. Methods: Gastrointestinal mesenchymal tumors identified by the Modena Cancer Registry between 1991 and 2004 were analyzed with an immunohistochemical panel that included staining for CD-117 and PDGFRα. Size, mitotic rate, and other pathologic parameters were recorded. Each tumor was categorized into National Institutes of Health risk categories (very low, low, intermediate, and high risk). Results: One hundred twenty-four cases were classified as GIST. The age-adjusted incidence rate was 6.6 per million. Seventy-five percent of patients were symptomatic; 34% had a previous or concomitant history of cancer. High-risk features were present in 47% of cases. Seventy-eight percent were submitted to radical surgery. After complete resection, the 5-year disease-free survival rates were 94%, 92%, 100%, and 40% for patients at very low, low, intermediate, and high risk, respectively. In multivariate analysis, high risk was the main predictor of recurrence. Conclusion: This population-based study shows that the incidence of GIST in Northern Italy is comparable to that reported in other European countries. Survival was favorable in lower risk categories and in most of the resected cases. In our study, resected patients at very low, low, and intermediate risk had a similar outcome. Our data support the need to consider high-risk patients after complete surgical resection for treatment with the best available approach.

Original languageEnglish
Article number230
JournalBMC Cancer
Volume7
DOIs
Publication statusPublished - Dec 20 2007

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Gastrointestinal Stromal Tumors
Incidence
Population
Neoplasms
Cohort Studies
National Institutes of Health (U.S.)
Italy
Disease-Free Survival
Registries
Epidemiology
Multivariate Analysis
Survival Rate
Staining and Labeling
Recurrence
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study. / Mucciarini, Claudia; Rossi, Giulio; Bertolini, Federica; Valli, Riccardo; Cirilli, Claudia; Rashid, Ivan; Marcheselli, Luigi; Luppi, Gabriele; Federico, Massimo.

In: BMC Cancer, Vol. 7, 230, 20.12.2007.

Research output: Contribution to journalArticle

Mucciarini, C, Rossi, G, Bertolini, F, Valli, R, Cirilli, C, Rashid, I, Marcheselli, L, Luppi, G & Federico, M 2007, 'Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study', BMC Cancer, vol. 7, 230. https://doi.org/10.1186/1471-2407-7-230
Mucciarini, Claudia ; Rossi, Giulio ; Bertolini, Federica ; Valli, Riccardo ; Cirilli, Claudia ; Rashid, Ivan ; Marcheselli, Luigi ; Luppi, Gabriele ; Federico, Massimo. / Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study. In: BMC Cancer. 2007 ; Vol. 7.
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abstract = "Background: Although the diagnostic criteria and pathogenesis of gastrointestinal stromal tumors (GIST) have recently been elucidated, knowledge of the epidemiology of this malignancy is still limited. This study examined the incidence of GIST in the province of Modena, including pathologic features and clinical outcome. Methods: Gastrointestinal mesenchymal tumors identified by the Modena Cancer Registry between 1991 and 2004 were analyzed with an immunohistochemical panel that included staining for CD-117 and PDGFRα. Size, mitotic rate, and other pathologic parameters were recorded. Each tumor was categorized into National Institutes of Health risk categories (very low, low, intermediate, and high risk). Results: One hundred twenty-four cases were classified as GIST. The age-adjusted incidence rate was 6.6 per million. Seventy-five percent of patients were symptomatic; 34{\%} had a previous or concomitant history of cancer. High-risk features were present in 47{\%} of cases. Seventy-eight percent were submitted to radical surgery. After complete resection, the 5-year disease-free survival rates were 94{\%}, 92{\%}, 100{\%}, and 40{\%} for patients at very low, low, intermediate, and high risk, respectively. In multivariate analysis, high risk was the main predictor of recurrence. Conclusion: This population-based study shows that the incidence of GIST in Northern Italy is comparable to that reported in other European countries. Survival was favorable in lower risk categories and in most of the resected cases. In our study, resected patients at very low, low, and intermediate risk had a similar outcome. Our data support the need to consider high-risk patients after complete surgical resection for treatment with the best available approach.",
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AU - Rossi, Giulio

AU - Bertolini, Federica

AU - Valli, Riccardo

AU - Cirilli, Claudia

AU - Rashid, Ivan

AU - Marcheselli, Luigi

AU - Luppi, Gabriele

AU - Federico, Massimo

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