Incidence and histological features of bone marrow involvement in malignant lymphomas

G. Lambertenghi-Deliliers, C. Annaloro, D. Soligo, A. Oriani, E. Pozzoli, N. Quirici, R. Luksch, E. E. Polli

Research output: Contribution to journalArticle

Abstract

Bone marrow biopsy (BMB) is a routine investigation in the diagnosis and staging of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL), and there is evidence supporting its prognostic importance in some histological varieties. The histological characteristics of BMB in 433 NHL and 155 HD patients were reviewed for clinicopathological correlations; 36 of these cases were also studied by means of immunohistochemistry. BM infiltrates were discovered in 171 NHL patients. In 36 cases, the diagnosis of NHL was directly established by BMB; a discordance between lymph node and BM histology was observed in 38 of the other 135 cases. BM-positive centroblastic and immunoblastic NHL were significantly associated with larger infiltrates, BM fibrosis, and megakaryocytic hyperplasia. Leukemization at diagnosis was more frequent in low-malignancy NHL. No correlation was found between histology and prognosis, although immunohistochemistry revealed a B-cell phenotype in all but two cases. BMB was positive in 18 of the 155 HD patients and directly diagnostic in two; Reed-Sternberg and Hodgkin cells were CD-30 positive and surrounded by T-cell infiltration. The concordance between BM and lymph node histology was fairly satisfactory, although the relationships between BM infiltration and other histological parameters may reflect peculiar interactions with BM microenvironmental factors. The usefulness of BMB in the diagnosis of malignant lymphomas has been demonstrated, and further progress can be expected from the availability of reliable immunohistochemical markers of clonality reacting on paraffin-embedded BM sections.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalAnnals of Hematology
Volume65
Issue number2
DOIs
Publication statusPublished - Aug 1992

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Non-Hodgkin's Lymphoma
Lymphoma
Bone Marrow
Hodgkin Disease
Incidence
Biopsy
Histology
Lymph Nodes
Immunohistochemistry
Reed-Sternberg Cells
Paraffin
Hyperplasia
Fibrosis
B-Lymphocytes
T-Lymphocytes
Phenotype
Neoplasms

Keywords

  • Bone marrow biopsy
  • Hodgkin's disease
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Lambertenghi-Deliliers, G., Annaloro, C., Soligo, D., Oriani, A., Pozzoli, E., Quirici, N., ... Polli, E. E. (1992). Incidence and histological features of bone marrow involvement in malignant lymphomas. Annals of Hematology, 65(2), 61-65. https://doi.org/10.1007/BF01698130

Incidence and histological features of bone marrow involvement in malignant lymphomas. / Lambertenghi-Deliliers, G.; Annaloro, C.; Soligo, D.; Oriani, A.; Pozzoli, E.; Quirici, N.; Luksch, R.; Polli, E. E.

In: Annals of Hematology, Vol. 65, No. 2, 08.1992, p. 61-65.

Research output: Contribution to journalArticle

Lambertenghi-Deliliers, G, Annaloro, C, Soligo, D, Oriani, A, Pozzoli, E, Quirici, N, Luksch, R & Polli, EE 1992, 'Incidence and histological features of bone marrow involvement in malignant lymphomas', Annals of Hematology, vol. 65, no. 2, pp. 61-65. https://doi.org/10.1007/BF01698130
Lambertenghi-Deliliers G, Annaloro C, Soligo D, Oriani A, Pozzoli E, Quirici N et al. Incidence and histological features of bone marrow involvement in malignant lymphomas. Annals of Hematology. 1992 Aug;65(2):61-65. https://doi.org/10.1007/BF01698130
Lambertenghi-Deliliers, G. ; Annaloro, C. ; Soligo, D. ; Oriani, A. ; Pozzoli, E. ; Quirici, N. ; Luksch, R. ; Polli, E. E. / Incidence and histological features of bone marrow involvement in malignant lymphomas. In: Annals of Hematology. 1992 ; Vol. 65, No. 2. pp. 61-65.
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