Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort

A. A. Schoemaker, A. B. Sprikkelman, K. E. Grimshaw, G. Roberts, L. Grabenhenrich, L. Rosenfeld, S. Siegert, R. Dubakiene, O. Rudzeviciene, M. Reche, A. Fiandor, N. G. Papadopoulos, A. Malamitsi-Puchner, A. Fiocchi, L. Dahdah, S. Th Sigurdardottir, M. Clausen, A. Stańczyk-Przyłuska, K. Zeman, E. N C MillsD. McBride, T. Keil, K. Beyer

Research output: Contribution to journalArticlepeer-review

Abstract

Background Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. Methods Children from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double-blind, placebo-controlled food challenge. Results Across Europe, 12 049 children were enrolled, and 9336 (77.5%) were followed up to 2 years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge-proven CMA of 0.54% (95% CI 0.41-0.70). National incidences ranged from 1% (in the Netherlands and UK) to

Original languageEnglish
Pages (from-to)963-972
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume70
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • birth cohort study
  • cow's milk allergy
  • EuroPrevall
  • food allergy
  • incidence

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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