OBJECTIVE: To evaluate the incidence and predictors of 30-day readmission in prostate cancer (PCa) patients treated with robot-assisted radical prostatectomy (RARP). PATIENTS AND METHODS: Overall, 1402 consecutive PCa patients treated with RARP at a single center between 2006 and 2013 were identified. Uni- and multivariate logistic regression analyses assessed predictors of 30-day readmission after surgery. RESULTS: Overall, 38 patients (2.7%) experienced hospital readmission within 30 days after discharge. The most common causes of rehospitalization were fever in 12 patients (31.6%), lymphoceles in 11 (28.9%), and urine leak in 6 (15.8%). By multivariable analyses, D'Amico risk group and occurrence of postoperative complications (odds ratio [OR], 2.89) represented independent predictors of 30-day readmission (all P ≤ .02). When analyzing the type of complication associated with the risk of readmission, fever (OR, 6.19; P = .01), urine leak (OR, 10.83; P <.01) and cardiocirculatory complications (OR, 18.57; P <.001) were significantly associated with 30-day readmission. CONCLUSION: Patients undergoing RARP have a relatively low risk of 30-day readmission (2.7%). The occurrence of an early postoperative complication and a higher D'Amico risk group were independent predictors of 30-day readmission. In addition, fever, urine leak, and cardiocirculatory complications are significantly associated with a higher risk of readmission. Copyright © 2016 Elsevier Inc. All rights reserved.