Incidence and predictors of acute symptomatic seizures after stroke

E. Beghi, R. D'Alessandro, S. Beretta, D. Consoli, V. Crespi, L. Delaj, C. Gandolfo, G. Greco, A. La Neve, M. Manfredi, F. Mattana, R. Musolino, L. Provinciali, M. Santangelo, L. M. Specchio, G. Zaccara

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Abstract

Objective: To assess incidence and predictors of acute symptomatic seizures in a prospective cohort of patients with first stroke. Methods: Patients with first stroke hospitalized in 31 Italian centers were recruited. Relevant demographic data, disease characteristics, and risk factors were collected. Acute symptomatic seizures (≤7 days) were recorded and correlated to age, gender, family history of epilepsy, and vascular risk factors. Results: A total of 714 patients (315 women, 399 men; age 27-97 years) were enrolled. A total of 609 (85.3%) had cerebral infarction (32 cerebral infarction with hemorrhagic transformation [CIHT]) and 105 (14.7%) primary intracerebral hemorrhage (PIH). A total of 141 (19.7%) had a large lesion (>3 cm) and 296 (41.5%) cortical involvement. Twelve patients reported family history of seizures. Forty-five patients (6.3%) presented acute symptomatic seizures, 24 with cerebral infarction (4.2%), 4 with CIHT (12.5%), and 17 (16.2%) with PIH. In multivariate analysis, compared to cerebral infarction, PIH carried the highest risk (odds ratio [OR] 7.2; 95% confidence interval [CI] 3.5-14.9) followed by CIHT (OR 2.7; 95% CI 0.8-9.6). Cortical involvement was a risk factor for PIH (OR 6.0; 95% CI 1.8-20.8) and for CI (OR 3.1; 95% CI 1.3-7.8). Hyperlipidemia (OR 0.2; 95% CI 0.03-0.8) was a protective factor for IPH. Conclusion: The incidence of acute symptomatic seizures is the highest reported in patients with first stroke with prospective follow-up. Hemorrhagic stroke and cortical lesion were independent predictors of acute symptomatic seizures. Hyperlipidemia was a protective factor for hemorrhagic stroke.

Original languageEnglish
Pages (from-to)1785-1793
Number of pages9
JournalNeurology
Volume77
Issue number20
DOIs
Publication statusPublished - Nov 15 2011

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ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Beghi, E., D'Alessandro, R., Beretta, S., Consoli, D., Crespi, V., Delaj, L., Gandolfo, C., Greco, G., Neve, A. L., Manfredi, M., Mattana, F., Musolino, R., Provinciali, L., Santangelo, M., Specchio, L. M., & Zaccara, G. (2011). Incidence and predictors of acute symptomatic seizures after stroke. Neurology, 77(20), 1785-1793. https://doi.org/10.1212/WNL.0b013e3182364878