Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis

Corrado Tamburino, Davide Capodanno, Angelo Ramondo, Anna Sonia Petronio, Federica Ettori, Gennaro Santoro, Silvio Klugmann, Francesco Bedogni, Francesco Maisano, Antonio Marzocchi, Arnaldo Poli, David Antoniucci, Massimo Napodano, Marco De Carlo, Claudia Fiorina, Gian Paolo Ussia

Research output: Contribution to journalArticlepeer-review

Abstract

Background- There is a lack of information on the incidence and predictors of early mortality at 30 days and late mortality between 30 days and 1 year after transcatheter aortic valve implantation (TAVI) with the self-expanding CoreValve Revalving prosthesis. Methods and Results- A total of 663 consecutive patients (mean age 81.0±7.3 years) underwent TAVI with the third generation 18-Fr CoreValve device in 14 centers. Procedural success and intraprocedural mortality were 98% and 0.9%, respectively. The cumulative incidences of mortality were 5.4% at 30 days, 12.2% at 6 months, and 15.0% at 1 year. The incidence density of mortality was 12.3 per 100 person-year of observation. Clinical and hemodynamic benefits observed acutely after TAVI were sustained at 1 year. Paravalvular leakages were trace to mild in the majority of cases. Conversion to open heart surgery (odds ratio [OR] 38.68), cardiac tamponade (OR 10.97), major access site complications (OR 8.47), left ventricular ejection fraction

Original languageEnglish
Pages (from-to)299-308
Number of pages10
JournalCirculation
Volume123
Issue number3
DOIs
Publication statusPublished - Jan 25 2011

Keywords

  • aortic stenosis
  • aortic valve
  • transcatheter aortic valve implantation
  • valve prosthesis

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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