Abstract
OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.
METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.
RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.
CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.
Original language | English |
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Pages (from-to) | 267.e1-267.e4 |
Journal | Clinical Microbiology and Infection |
Volume | 23 |
Issue number | 4 |
Early online date | Dec 9 2016 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Journal Article