Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

M. Puoti, P Lorenzini, A. Lepri Cozzi, A Gori, C. Mastroianni, G. Rizzardini, G. Mazzarello, A Antinori, A. d'Arminio Monforte, E Girardi, Icona Foundation Study Group, Alessandra Latini, Antonio Cristaudo

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.

METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.

RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.

CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

Original languageEnglish
Pages (from-to)267.e1-267.e4
JournalClinical Microbiology and Infection
Volume23
Issue number4
Early online dateDec 9 2016
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Journal Article

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