Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

M. Puoti; P Lorenzini; A. Lepri Cozzi; A Gori; C. Mastroianni; G. Rizzardini; G. Mazzarello; A Antinori; A. d'Arminio Monforte; E Girardi; Icona Foundation Study Group; Alessandra Latini; Antonio Cristaudo

doi:10.1016/j.cmi.2016.12.003

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

M. Puoti, P Lorenzini, A. Lepri Cozzi, A Gori, C. Mastroianni, G. Rizzardini, G. Mazzarello, A Antinori, A. d'Arminio Monforte, E Girardi, Icona Foundation Study Group, Alessandra Latini, Antonio Cristaudo

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.

METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.

RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.

CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

Original language	English
Pages (from-to)	267.e1-267.e4
Journal	Clinical Microbiology and Infection
Volume	23
Issue number	4
Early online date	Dec 9 2016
DOIs	https://doi.org/10.1016/j.cmi.2016.12.003
Publication status	Published - Apr 2017

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Puoti, M., Lorenzini, P., Lepri Cozzi, A., Gori, A., Mastroianni, C., Rizzardini, G., Mazzarello, G., Antinori, A., d'Arminio Monforte, A., Girardi, E., Icona Foundation Study Group, Latini, A., & Cristaudo, A. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. Clinical Microbiology and Infection, 23(4), 267.e1-267.e4. https://doi.org/10.1016/j.cmi.2016.12.003

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. / Puoti, M.; Lorenzini, P; Lepri Cozzi, A.; Gori, A; Mastroianni, C.; Rizzardini, G.; Mazzarello, G.; Antinori, A; d'Arminio Monforte, A.; Girardi, E; Icona Foundation Study Group ; Latini, Alessandra ; Cristaudo, Antonio.

In: Clinical Microbiology and Infection, Vol. 23, No. 4, 04.2017, p. 267.e1-267.e4.

Research output: Contribution to journal › Article › peer-review

Puoti, M, Lorenzini, P, Lepri Cozzi, A, Gori, A, Mastroianni, C, Rizzardini, G, Mazzarello, G, Antinori, A, d'Arminio Monforte, A, Girardi, E, Icona Foundation Study Group, Latini, A & Cristaudo, A 2017, 'Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus', Clinical Microbiology and Infection, vol. 23, no. 4, pp. 267.e1-267.e4. https://doi.org/10.1016/j.cmi.2016.12.003

Puoti, M. ; Lorenzini, P ; Lepri Cozzi, A. ; Gori, A ; Mastroianni, C. ; Rizzardini, G. ; Mazzarello, G. ; Antinori, A ; d'Arminio Monforte, A. ; Girardi, E ; Icona Foundation Study Group ; Latini, Alessandra ; Cristaudo, Antonio. / Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. In: Clinical Microbiology and Infection. 2017 ; Vol. 23, No. 4. pp. 267.e1-267.e4.

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abstract = "OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.",

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T1 - Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

AU - Puoti, M.

AU - Lorenzini, P

AU - Lepri Cozzi, A.

AU - Gori, A

AU - Mastroianni, C.

AU - Rizzardini, G.

AU - Mazzarello, G.

AU - Antinori, A

AU - d'Arminio Monforte, A.

AU - Girardi, E

AU - Icona Foundation Study Group

AU - Latini, Alessandra

AU - Cristaudo, Antonio

PY - 2017/4

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N2 - OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

AB - OBJECTIVE: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.METHODS: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.RESULTS: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.CONCLUSIONS: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

KW - Journal Article

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DO - 10.1016/j.cmi.2016.12.003

M3 - Article

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JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 4

ER -

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

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