Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

M. Puoti, P. Lorenzini, A. Lepri Cozzi, A. Gori, C. Mastroianni, G. Rizzardini, G. Mazzarello, A. Antinori, A. d'Arminio Monforte, E. Girardi

Research output: Contribution to journalArticle

Abstract

Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals. © 2016 European Society of Clinical Microbiology and Infectious Diseases.
Original languageEnglish
JournalClinical Microbiology and Infection
DOIs
Publication statusPublished - 2016

Keywords

  • Cirrhosis
  • Cohort study
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Incidence

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