Incidence and risk factors of duodenal ulcer

A retrospective cohort study

Claudio Leoci, Enzo Ierardi, Marisa Chiloiro, Elettra Piccioli, Giovanni DiMatteo, Giovanni Misciagna, Italo Giorgio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We evaluated the incidence and risk factors of duodenal ulcer (DU) in a cohort of patients who had undergone esophagogastroduodenoscopy in our institution from 1978 to 1982, without then finding a gastric or duodenal ulcer. Six hundred and twenty-one subjects entered the study, and 526 (84.7%) were traced in 1992. Forty-one cases of DU were found, an incidence rate of 6.7 per 1,000 person-years; the male/female ratio was 2:1. The diagnoses of peptic ulcer (PU) were validated by means of medical documentation. The odds ratio of DU was 2.3 (95% confidence interval 0.8–6.3) and 3.5 (1.4–9.0) in the 11 and III tertile of basal acid output (BAO) compared with the I tertile, and 2.6 (0.8–8.3) and 7.0 (2.3–20.7) in the II and III tertile of maximal acid output (MAO) compared with the I tertile. Cigarette smoking and the presence of PU among siblings of DU patients were risk factors for DU. Multiple logistic regression confirmed only the association of DU with MAO, cigarette smoking, and family history. By means of a nested case-control study, the risk of developing DU was assessed in subjects with Helicobacter pylori (HP) at the biopsy of gastric mucosa performed before the ulcer diagnosis. The odds ratio of DU in HP-positive subjects was 5.0 (95% confidence interval 0.6–45). The results of this study confirm the influence of gastric acid secretion, cigarette smoking, and family history in the pathogenesis of DU and suggest that HP infection not only favors relapse but could have an important role in the onset of the disease.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume20
Issue number2
Publication statusPublished - 1995

Fingerprint

Duodenal Ulcer
Cohort Studies
Retrospective Studies
Incidence
Helicobacter pylori
Smoking
Peptic Ulcer
Acids
Odds Ratio
Confidence Intervals
Digestive System Endoscopy
Gastric Acid
Helicobacter Infections
Stomach Ulcer
Gastric Mucosa
Documentation
Ulcer
Case-Control Studies
Siblings
Logistic Models

Keywords

  • Duodenal ulcer
  • Gastric acid secretion
  • Helicobacter pylori
  • Retrospective cohort study
  • Risk factors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Leoci, C., Ierardi, E., Chiloiro, M., Piccioli, E., DiMatteo, G., Misciagna, G., & Giorgio, I. (1995). Incidence and risk factors of duodenal ulcer: A retrospective cohort study. Journal of Clinical Gastroenterology, 20(2), 104-109.

Incidence and risk factors of duodenal ulcer : A retrospective cohort study. / Leoci, Claudio; Ierardi, Enzo; Chiloiro, Marisa; Piccioli, Elettra; DiMatteo, Giovanni; Misciagna, Giovanni; Giorgio, Italo.

In: Journal of Clinical Gastroenterology, Vol. 20, No. 2, 1995, p. 104-109.

Research output: Contribution to journalArticle

Leoci, C, Ierardi, E, Chiloiro, M, Piccioli, E, DiMatteo, G, Misciagna, G & Giorgio, I 1995, 'Incidence and risk factors of duodenal ulcer: A retrospective cohort study', Journal of Clinical Gastroenterology, vol. 20, no. 2, pp. 104-109.
Leoci C, Ierardi E, Chiloiro M, Piccioli E, DiMatteo G, Misciagna G et al. Incidence and risk factors of duodenal ulcer: A retrospective cohort study. Journal of Clinical Gastroenterology. 1995;20(2):104-109.
Leoci, Claudio ; Ierardi, Enzo ; Chiloiro, Marisa ; Piccioli, Elettra ; DiMatteo, Giovanni ; Misciagna, Giovanni ; Giorgio, Italo. / Incidence and risk factors of duodenal ulcer : A retrospective cohort study. In: Journal of Clinical Gastroenterology. 1995 ; Vol. 20, No. 2. pp. 104-109.
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