Abstract
A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).
| Original language | English |
|---|---|
| Pages (from-to) | 1592-1596 |
| Number of pages | 5 |
| Journal | European Journal of Cancer |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Sep 1997 |
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Keywords
- Deep vein thrombosis
- High-grade gliomas
- Prophylaxis
- Pulmonary embolism
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Incidence and risk of thromboembolism during treatment of high-grade gliomas : A prospective study. / Brandes, A. A.; Scelzi, E.; Salmistraro, G.; Ermani, M.; Carollo, C.; Berti, F.; Zampieri, P.; Baiocchi, C.; Fiorentino, M. V.
In: European Journal of Cancer, Vol. 33, No. 10, 09.1997, p. 1592-1596.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence and risk of thromboembolism during treatment of high-grade gliomas
T2 - A prospective study
AU - Brandes, A. A.
AU - Scelzi, E.
AU - Salmistraro, G.
AU - Ermani, M.
AU - Carollo, C.
AU - Berti, F.
AU - Zampieri, P.
AU - Baiocchi, C.
AU - Fiorentino, M. V.
PY - 1997/9
Y1 - 1997/9
N2 - A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).
AB - A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).
KW - Deep vein thrombosis
KW - High-grade gliomas
KW - Prophylaxis
KW - Pulmonary embolism
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UR - http://www.scopus.com/inward/citedby.url?scp=0031418172&partnerID=8YFLogxK
U2 - 10.1016/S0959-8049(97)00167-6
DO - 10.1016/S0959-8049(97)00167-6
M3 - Article
VL - 33
SP - 1592
EP - 1596
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 10
ER -