Incidence and risk of thromboembolism during treatment of high-grade gliomas

A prospective study

A. A. Brandes, E. Scelzi, G. Salmistraro, M. Ermani, C. Carollo, F. Berti, P. Zampieri, C. Baiocchi, M. V. Fiorentino

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).

Original languageEnglish
Pages (from-to)1592-1596
Number of pages5
JournalEuropean Journal of Cancer
Volume33
Issue number10
DOIs
Publication statusPublished - Sep 1997

Fingerprint

Thromboembolism
Glioma
Venous Thrombosis
Prospective Studies
Incidence
Paresis
Adjuvant Chemoradiotherapy
Astrocytoma
Therapeutics
Glioblastoma
Pulmonary Embolism
Histology
Adrenal Cortex Hormones
Drug Therapy

Keywords

  • Deep vein thrombosis
  • High-grade gliomas
  • Prophylaxis
  • Pulmonary embolism

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Brandes, A. A., Scelzi, E., Salmistraro, G., Ermani, M., Carollo, C., Berti, F., ... Fiorentino, M. V. (1997). Incidence and risk of thromboembolism during treatment of high-grade gliomas: A prospective study. European Journal of Cancer, 33(10), 1592-1596. https://doi.org/10.1016/S0959-8049(97)00167-6

Incidence and risk of thromboembolism during treatment of high-grade gliomas : A prospective study. / Brandes, A. A.; Scelzi, E.; Salmistraro, G.; Ermani, M.; Carollo, C.; Berti, F.; Zampieri, P.; Baiocchi, C.; Fiorentino, M. V.

In: European Journal of Cancer, Vol. 33, No. 10, 09.1997, p. 1592-1596.

Research output: Contribution to journalArticle

Brandes, AA, Scelzi, E, Salmistraro, G, Ermani, M, Carollo, C, Berti, F, Zampieri, P, Baiocchi, C & Fiorentino, MV 1997, 'Incidence and risk of thromboembolism during treatment of high-grade gliomas: A prospective study', European Journal of Cancer, vol. 33, no. 10, pp. 1592-1596. https://doi.org/10.1016/S0959-8049(97)00167-6
Brandes, A. A. ; Scelzi, E. ; Salmistraro, G. ; Ermani, M. ; Carollo, C. ; Berti, F. ; Zampieri, P. ; Baiocchi, C. ; Fiorentino, M. V. / Incidence and risk of thromboembolism during treatment of high-grade gliomas : A prospective study. In: European Journal of Cancer. 1997 ; Vol. 33, No. 10. pp. 1592-1596.
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