Incidence and risk of thromboembolism during treatment of high-grade gliomas: A prospective study

A. A. Brandes, E. Scelzi, G. Salmistraro, M. Ermani, C. Carollo, F. Berti, P. Zampieri, C. Baiocchi, M. V. Fiorentino

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A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).

Original languageEnglish
Pages (from-to)1592-1596
Number of pages5
JournalEuropean Journal of Cancer
Issue number10
Publication statusPublished - Sep 1997


  • Deep vein thrombosis
  • High-grade gliomas
  • Prophylaxis
  • Pulmonary embolism

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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