Incidence and survival of childhood central nervous system tumors in the region of Lombardy

G. Filippini, M. Farinotti, M. Ferrarini

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The main objective of the study was to calculate incidence rates for CNS tumors in the 0-14 age group of the population of the Lombardy Region in the period 19881993. Primitive CNS tumors defined according the ICD-O codes, were actively searched. Incidence rates were computed on the basis of the resident population as taken from the 1991 decennial census (1,231,299 children). Age standardised annual incidence rates (ASR) per million children were calculated by the direct method using the world standard population. For each child detected vital status on December 31, 1995 was assessed. During the six year study period CNS tumors were diagnosed in 296 children. The ASR was 40.0/million for both sexes, 45.1 for males and 34.4/million for females. Astocytomas, with an ASR of 13.7/million had the highest incidence of all CNS tumors. Medulloblastoma/ PNET and ependymomas had ASRs of 7.0 and 5.8/million respectively. The rate for other gliomas was 2.1 ; for other intracranial and spinal tumors the rate was 11.3/million. Survival was 68% at 5 years. Prognosis was good for astrocytoma (5-year survival, 81%), other glioma (5-year survival, 76%) and ependymoma (5-year survival, 62%). Age classes 0-1 and 10-14 years showed a lower risk (respectively RR = 0.72 and RR = 0.68) than age class 1-4 (RR= 1.81).

Original languageEnglish
Pages (from-to)39
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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