Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: A survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group

Simone Cesaro, A. Brugiolo, M. Faraci, C. Uderzo, R. Rondelli, C. Favre, M. Zecca, G. Garetto, G. Dini, M. Pillon, C. Messina, L. Zanesco, A. Pession, F. Locatelli

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this multicenter study was to assess the incidence and the treatment of hemorrhagic cystitis (HC) in 1218 pediatric patients, with a mean age of 10.8 years, who underwent hematopoietic stem cell transplantation (HSCT). In all, 44 patients (3.6%) developed HC a median 23 days after HSCT. The incidence of HC was higher in allogeneic than in autologous HSCT recipients (P = 0.0001). Of the 44 patients, 37 (84%) recovered from HC in a median 30 days (range 3-100); the other seven children died while still suffering from HC. Hyperbaric oxygen therapy (HOT) achieved significantly better results than prostaglandin therapy (P = 0.02) in the treatment of grade II-III HC. By multivariate analysis, age

Original languageEnglish
Pages (from-to)925-931
Number of pages7
JournalBone Marrow Transplantation
Volume32
Issue number9
DOIs
Publication statusPublished - Nov 2003

Keywords

  • BK virus
  • Hemorrhagic cystitis
  • Hyperbaric oxygen therapy
  • Pediatric hematopoietic stem cell transplantation
  • Prostaglandins

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint

Dive into the research topics of 'Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: A survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group'. Together they form a unique fingerprint.

Cite this