TY - JOUR
T1 - Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation
T2 - A survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group
AU - Cesaro, Simone
AU - Brugiolo, A.
AU - Faraci, M.
AU - Uderzo, C.
AU - Rondelli, R.
AU - Favre, C.
AU - Zecca, M.
AU - Garetto, G.
AU - Dini, G.
AU - Pillon, M.
AU - Messina, C.
AU - Zanesco, L.
AU - Pession, A.
AU - Locatelli, F.
PY - 2003/11
Y1 - 2003/11
N2 - The purpose of this multicenter study was to assess the incidence and the treatment of hemorrhagic cystitis (HC) in 1218 pediatric patients, with a mean age of 10.8 years, who underwent hematopoietic stem cell transplantation (HSCT). In all, 44 patients (3.6%) developed HC a median 23 days after HSCT. The incidence of HC was higher in allogeneic than in autologous HSCT recipients (P = 0.0001). Of the 44 patients, 37 (84%) recovered from HC in a median 30 days (range 3-100); the other seven children died while still suffering from HC. Hyperbaric oxygen therapy (HOT) achieved significantly better results than prostaglandin therapy (P = 0.02) in the treatment of grade II-III HC. By multivariate analysis, age
AB - The purpose of this multicenter study was to assess the incidence and the treatment of hemorrhagic cystitis (HC) in 1218 pediatric patients, with a mean age of 10.8 years, who underwent hematopoietic stem cell transplantation (HSCT). In all, 44 patients (3.6%) developed HC a median 23 days after HSCT. The incidence of HC was higher in allogeneic than in autologous HSCT recipients (P = 0.0001). Of the 44 patients, 37 (84%) recovered from HC in a median 30 days (range 3-100); the other seven children died while still suffering from HC. Hyperbaric oxygen therapy (HOT) achieved significantly better results than prostaglandin therapy (P = 0.02) in the treatment of grade II-III HC. By multivariate analysis, age
KW - BK virus
KW - Hemorrhagic cystitis
KW - Hyperbaric oxygen therapy
KW - Pediatric hematopoietic stem cell transplantation
KW - Prostaglandins
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UR - http://www.scopus.com/inward/citedby.url?scp=10744225309&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1704252
DO - 10.1038/sj.bmt.1704252
M3 - Article
C2 - 14561994
AN - SCOPUS:10744225309
VL - 32
SP - 925
EP - 931
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 9
ER -