Incidence, Characteristics, Predictors, and Outcomes of Repeat Revascularization After Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting: The SYNTAX Trial at 5 Years

Catalina A. Parasca, Stuart J. Head, Milan Milojevic, Michael J. Mack, Patrick W. Serruys, Marie Claude Morice, Friedrich W. Mohr, Ted E. Feldman, Antonio Colombo, Keith D. Dawkins, David R. Holmes, Pieter A. Kappetein, SYNTAX Investigators

Research output: Contribution to journalArticle

Abstract

Objectives The study sought to determine the incidence, predictors, characteristics, and outcomes of repeat revascularization during 5-year follow-up of the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) trial. Background Limited in-depth long-term data on repeat revascularization are available from randomized trials comparing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Methods Incidence and timing of repeat revascularization and its relation to the long-term composite safety endpoint of death, stroke, and myocardial infarction were analyzed in the SYNTAX trial (n = 1,800) using Kaplan-Meier analysis. Results At 5 years, repeat revascularization occurred more often after initial PCI than after initial CABG (25.9% vs. 13.7%, respectively; p < 0.001), and more often consisted of multiple repeat revascularizations (9.0% vs. 2.8%, respectively; p = 0.022). Significantly more repeat PCI procedures were performed on de novo lesions in patients after initial PCI than initial CABG (33.3% vs. 13.4%, respectively; p < 0.001). At 5-year follow-up, patients who underwent repeat revascularization versus patients not undergoing repeat revascularization had significantly higher rates of the composite safety endpoint of death, stroke, and myocardial infarction after initial PCI (33.8% vs. 16.6%, respectively; p < 0.001), and a trend was found after initial CABG (22.4% vs. 15.8%, respectively; p = 0.07). After multivariate adjustment, repeat revascularization was an independent predictor of the composite safety endpoint after both initial PCI (hazard ratio [HR]: 2.2; 95% confidence interval [CI]: 1.6 to 3.0; p < 0.001) and initial CABG (HR: 1.8; 95% CI: 1.2 to 2.9; p = 0.011). Conclusions Repeat revascularization rates are significantly higher after initial PCI than after initial CABG for complex coronary disease. Repeat revascularization is an independent predictor of death, stroke, and myocardial infarction for myocardial revascularization.

Original languageEnglish
Pages (from-to)2493-2507
Number of pages15
JournalJACC: Cardiovascular Interventions
Volume9
Issue number24
DOIs
Publication statusPublished - Dec 26 2016

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Keywords

  • coronary artery bypass grafting
  • percutaneous coronary intervention
  • repeat revascularization
  • SYNTAX

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Parasca, C. A., Head, S. J., Milojevic, M., Mack, M. J., Serruys, P. W., Morice, M. C., Mohr, F. W., Feldman, T. E., Colombo, A., Dawkins, K. D., Holmes, D. R., Kappetein, P. A., & SYNTAX Investigators (2016). Incidence, Characteristics, Predictors, and Outcomes of Repeat Revascularization After Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting: The SYNTAX Trial at 5 Years. JACC: Cardiovascular Interventions, 9(24), 2493-2507. https://doi.org/10.1016/j.jcin.2016.09.044