Incidence of AIDS-defining cancers after AIDS diagnosis among people with AIDS in Italy, 1986-1998

Silvia Franceschi, Luigino Dal Maso, Patrizio Pezzotti, Jerry Polesel, Claudia Braga, Pierluca Piselli, Diego Serraino, Giovanna Tagliabue, Massimo Federico, Stefano Ferretti, Vincenzo De Lisi, Francesco La Rosa, Ettore Conti, Mario Budroni, Gianni Vicario, Silvano Piffer, Franco Pannelli, Adriano Giacomin, Francesco Bellù, Rosario Tumino & 2 others Mario Fusco, Giovanni Rezza

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A record linkage was carried out between the Italian National Registry of AIDS and 19 cancer registries. The aim was to evaluate the 1986 through 1998 trends in incidence rate (IR) of AIDS-defining cancers (ADCs) among persons with AIDS (PWA) in Italy overall and according to various characteristics. A steady decrease in IRs was found for Kaposi sarcoma (KS) in men between 1986-1992 (2.5 per 100 person-years [py]) and 1997-1998 (1.0 per 100 py). Conversely, the first decrease in IRs of KS in women (from 0.9 to 0.6 per 100 py) and of non-Hodgkin lymphoma in both genders (from 1.7 to 0.7 per 100 py) was seen between 1993-1996 and 1997-1998, thus pointing to a favorable impact of highly active antiretroviral therapies. The decline was consistent across different age and HIV transmission groups, but it was more marked in PWA with a CD4 count >50 cells/μL than in PWA with more severe immune suppression. As a proportion of AIDS cases, invasive cervical cancer increased from 1.5% in 1993-1996 to 2.4% in 1997-1998, but IRs after AIDS could not be evaluated. On account of the marked decline of KS in men in 1997-1998, the overall burden of ADCs in Italy became similar in both genders.

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number1
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Italy
Acquired Immunodeficiency Syndrome
Incidence
Kaposi's Sarcoma
Neoplasms
Registries
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Uterine Cervical Neoplasms
Non-Hodgkin's Lymphoma
HIV

Keywords

  • AIDS
  • Incidence
  • Invasive cervical cancer
  • Kaposi sarcoma
  • Linkage
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Incidence of AIDS-defining cancers after AIDS diagnosis among people with AIDS in Italy, 1986-1998. / Franceschi, Silvia; Dal Maso, Luigino; Pezzotti, Patrizio; Polesel, Jerry; Braga, Claudia; Piselli, Pierluca; Serraino, Diego; Tagliabue, Giovanna; Federico, Massimo; Ferretti, Stefano; De Lisi, Vincenzo; La Rosa, Francesco; Conti, Ettore; Budroni, Mario; Vicario, Gianni; Piffer, Silvano; Pannelli, Franco; Giacomin, Adriano; Bellù, Francesco; Tumino, Rosario; Fusco, Mario; Rezza, Giovanni.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 34, No. 1, 01.09.2003, p. 84-90.

Research output: Contribution to journalArticle

Franceschi, S, Dal Maso, L, Pezzotti, P, Polesel, J, Braga, C, Piselli, P, Serraino, D, Tagliabue, G, Federico, M, Ferretti, S, De Lisi, V, La Rosa, F, Conti, E, Budroni, M, Vicario, G, Piffer, S, Pannelli, F, Giacomin, A, Bellù, F, Tumino, R, Fusco, M & Rezza, G 2003, 'Incidence of AIDS-defining cancers after AIDS diagnosis among people with AIDS in Italy, 1986-1998', Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 1, pp. 84-90. https://doi.org/10.1097/00126334-200309010-00013
Franceschi, Silvia ; Dal Maso, Luigino ; Pezzotti, Patrizio ; Polesel, Jerry ; Braga, Claudia ; Piselli, Pierluca ; Serraino, Diego ; Tagliabue, Giovanna ; Federico, Massimo ; Ferretti, Stefano ; De Lisi, Vincenzo ; La Rosa, Francesco ; Conti, Ettore ; Budroni, Mario ; Vicario, Gianni ; Piffer, Silvano ; Pannelli, Franco ; Giacomin, Adriano ; Bellù, Francesco ; Tumino, Rosario ; Fusco, Mario ; Rezza, Giovanni. / Incidence of AIDS-defining cancers after AIDS diagnosis among people with AIDS in Italy, 1986-1998. In: Journal of Acquired Immune Deficiency Syndromes. 2003 ; Vol. 34, No. 1. pp. 84-90.
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AU - Piselli, Pierluca

AU - Serraino, Diego

AU - Tagliabue, Giovanna

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AU - Ferretti, Stefano

AU - De Lisi, Vincenzo

AU - La Rosa, Francesco

AU - Conti, Ettore

AU - Budroni, Mario

AU - Vicario, Gianni

AU - Piffer, Silvano

AU - Pannelli, Franco

AU - Giacomin, Adriano

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