Incidence of bacteremias and invasive mycoses in children with acute non-lymphoblastic leukemia: Results from a multi-center Italian study

Elio Castagnola, Mario R. Rossi, Simone Cesaro, Susanna Livadiotti, Mareva Giacchino, Giulio Zanazzo, Francesca Fioredda, Chiara Beretta, Francesca Ciocchello, Modesto Carli, Maria Caterina Putti, Valeria Pansini, Massimo Berger, Maria Licciardello, Silvia Farina, Ilaria Caviglia, Riccardo Haupt

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Data on the epidemiology of bacteremias and invasive fungal diseases (IFD) in children with acute myeloid leukemia (AML) are scarce. Design and Methods: In a multi-center, retrospective study, we analyzed proportion, rate per 1,000 person-days at risk, and cumulative risk of bacteremias and IFD in children with AML. Results: Between January 1998 and December 2005, 240 children were treated for AML at 8 Italian Centers, for a total of 521 treatment courses and 63,232 person-days at risk. Bacteremia was observed in 32% of treatment courses and IFD was seen in 10% (P <0.0001), with rates of 2.62 and 0.84, respectively (P <0.001). There was a significantly higher frequency of IFD during relapse treatment: proportion 15% versus 9% (P = 0.05), rate 2.10 versus 0.64 (P = 0.008) and cumulative risk 32% versus 12% (P = 0.007), while there were no differences in the proportion, rate and cumulative risk of bacteremia during front-line or relapse treatment. The epidemiology of bacteremias and IFD was different during front-line therapy for M3 as compared to other types of AML, but the differences were not statistically significant. Conclusions: Severe infectious complications are frequent during the treatment of pediatric AML, especially during relapse treatment, and bacteremias are more frequent than IFD.

Original languageEnglish
Pages (from-to)1103-1107
Number of pages5
JournalPediatric Blood and Cancer
Volume55
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Acute non-lymphoblastic leukemia
  • Bacteremia
  • Invasive mycosis
  • Pediatrics

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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