Incidence of cancer after immunosuppressive treatment for heart transplantation

Giovanbattista Ippoliti, Mauro Rinaldi, Carlo Pellegrini, Mario Viganò

Research output: Contribution to journalArticlepeer-review

Abstract

Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incidence of lymphomas in cardiac versus renal patients. Moreover, a two-fold greater increase of all neoplasms was found in cardiac recipients, with nearly a six-fold increase in visceral tumors. Several factors may account for these differences. In cardiac allograft recipients, intensive immunosuppression is frequently used to reverse acute rejection and the highest number of cardiac transplants was performed in the era of polypharmacy, usually consisting of triple therapy.

Original languageEnglish
Pages (from-to)101-113
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Volume56
Issue number1 SPEC. ISS.
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Acute rejection
  • Immunosuppression
  • Infection
  • Lymphoma
  • Risk factor
  • Solid tumor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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