Abstract
Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incidence of lymphomas in cardiac versus renal patients. Moreover, a two-fold greater increase of all neoplasms was found in cardiac recipients, with nearly a six-fold increase in visceral tumors. Several factors may account for these differences. In cardiac allograft recipients, intensive immunosuppression is frequently used to reverse acute rejection and the highest number of cardiac transplants was performed in the era of polypharmacy, usually consisting of triple therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 101-113 |
| Number of pages | 13 |
| Journal | Critical Reviews in Oncology/Hematology |
| Volume | 56 |
| Issue number | 1 SPEC. ISS. |
| DOIs | |
| Publication status | Published - Oct 2005 |
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Keywords
- Acute rejection
- Immunosuppression
- Infection
- Lymphoma
- Risk factor
- Solid tumor
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Incidence of cancer after immunosuppressive treatment for heart transplantation. / Ippoliti, Giovanbattista; Rinaldi, Mauro; Pellegrini, Carlo; Viganò, Mario.
In: Critical Reviews in Oncology/Hematology, Vol. 56, No. 1 SPEC. ISS., 10.2005, p. 101-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence of cancer after immunosuppressive treatment for heart transplantation
AU - Ippoliti, Giovanbattista
AU - Rinaldi, Mauro
AU - Pellegrini, Carlo
AU - Viganò, Mario
PY - 2005/10
Y1 - 2005/10
N2 - Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incidence of lymphomas in cardiac versus renal patients. Moreover, a two-fold greater increase of all neoplasms was found in cardiac recipients, with nearly a six-fold increase in visceral tumors. Several factors may account for these differences. In cardiac allograft recipients, intensive immunosuppression is frequently used to reverse acute rejection and the highest number of cardiac transplants was performed in the era of polypharmacy, usually consisting of triple therapy.
AB - Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incidence of lymphomas in cardiac versus renal patients. Moreover, a two-fold greater increase of all neoplasms was found in cardiac recipients, with nearly a six-fold increase in visceral tumors. Several factors may account for these differences. In cardiac allograft recipients, intensive immunosuppression is frequently used to reverse acute rejection and the highest number of cardiac transplants was performed in the era of polypharmacy, usually consisting of triple therapy.
KW - Acute rejection
KW - Immunosuppression
KW - Infection
KW - Lymphoma
KW - Risk factor
KW - Solid tumor
UR - http://www.scopus.com/inward/record.url?scp=24644437846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24644437846&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2005.03.013
DO - 10.1016/j.critrevonc.2005.03.013
M3 - Article
C2 - 15979322
AN - SCOPUS:24644437846
VL - 56
SP - 101
EP - 113
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
IS - 1 SPEC. ISS.
ER -