Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

Moran Amit, Yoav Binenbaum, Kanika Sharma, Naomi Ramer, Ilana Ramer, Abib Agbetoba, Joelle Glick, Xinjie Yang, Delin Lei, Kristine Bjørndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, Dan Fliss, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Frank Palmer, Ian Ganly, Snehal PatelZiv Gil

Research output: Contribution to journalArticle

Abstract

Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p =.001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p =.017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.

Original languageEnglish
Pages (from-to)1032-1037
Number of pages6
JournalHead and Neck
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Adenoid Cystic Carcinoma
Neck Dissection
Lymph Nodes
Neoplasm Metastasis
Neck
Incidence
Mouth
Multivariate Analysis
Salivary Glands
Survival Rate
Head
Survival
Therapeutics

Keywords

  • adenoid cystic carcinoma
  • incidence
  • lymph node
  • metastasis
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. / Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Ramer, Naomi; Ramer, Ilana; Agbetoba, Abib; Glick, Joelle; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus Dietrich; Fliss, Dan; Eckardt, André M.; Copelli, Chiara; Sesenna, Enrico; Palmer, Frank; Ganly, Ian; Patel, Snehal; Gil, Ziv.

In: Head and Neck, Vol. 37, No. 7, 01.07.2015, p. 1032-1037.

Research output: Contribution to journalArticle

Amit, M, Binenbaum, Y, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A, Glick, J, Yang, X, Lei, D, Bjørndal, K, Godballe, C, Mücke, T, Wolff, KD, Fliss, D, Eckardt, AM, Copelli, C, Sesenna, E, Palmer, F, Ganly, I, Patel, S & Gil, Z 2015, 'Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study', Head and Neck, vol. 37, no. 7, pp. 1032-1037. https://doi.org/10.1002/hed.23711
Amit, Moran ; Binenbaum, Yoav ; Sharma, Kanika ; Ramer, Naomi ; Ramer, Ilana ; Agbetoba, Abib ; Glick, Joelle ; Yang, Xinjie ; Lei, Delin ; Bjørndal, Kristine ; Godballe, Christian ; Mücke, Thomas ; Wolff, Klaus Dietrich ; Fliss, Dan ; Eckardt, André M. ; Copelli, Chiara ; Sesenna, Enrico ; Palmer, Frank ; Ganly, Ian ; Patel, Snehal ; Gil, Ziv. / Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. In: Head and Neck. 2015 ; Vol. 37, No. 7. pp. 1032-1037.
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