Incidenza délie anomalie cromosomiche e délie malformazioni congenite nei bambini nati da procreazione medicalmente assistita

Translated title of the contribution: Incidence of chromosomal anomalies and congenital malformations in babies born from assisted reproductive tecniques

Giovanni Battista, L. A. Sala, Rossella Montanari

Research output: Contribution to journalArticlepeer-review

Abstract

The introduction and widespread application of Assisted Reproductive Techniques (ART) have raised major concern about the offspring 's health.The incidence of congenital and chromosomal anomalies after standard In Vitro Fertilization and Embryo Transfer seems to be similar to that expected in the general population. The prevalence of congenital malformations does not seem to be higher in children conceived by IGSI. On the other hand, it seems that there is a slight risk for trasmission of chromosomal aberration of paternal origin and a certain risk of de novo sex-chromosomal and strucural aberrations after ICSI.We report the results of the followup of 938 children conceived in our pubblic ART by standard IVF(649) and by ICS1(289) from 21-2-1987 to 306-1999. The incidence of the congenital malformations results of the 1.8% (17/938); the incidence of chromosomal anomalies results 0.5% (5/938). The incidence of congenital malformations and chromosomal anomalies results 1.5% (10/649) and 0.6% (4/649), respectively, for standard 1VF and 2.4% (7/289) and 0.3% (1/289) for ICSI. Our data seems to be reassuring but the incidence of chromosomal anomalies in ICSI children needs further investigation.

Translated title of the contributionIncidence of chromosomal anomalies and congenital malformations in babies born from assisted reproductive tecniques
Original languageItalian
Pages (from-to)473-478
Number of pages6
JournalActa Biomedica
Volume71
Issue numberSUPPL. 1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Medicine(all)

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