Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy

D. Caselli; S. Cesaro; F. Fagioli; F. Carraro; Ottavio Ziino; Giulio Andrea Zanazzo; Cristina Meazza; Antonella Colombini; Elio Castagnola; Paola Muggeo; Rossella Mura; M. G. Orofino; M. Giacchino; M. La Spina; Caterina Consarino; Fabio Tucci; Angelica Barone; M. Cellini; K. Perruccio; Roberto Bandettini; R. Rondelli; S. De Masi; Maurizio Aricò

doi:10.3109/23744235.2015.1087647

Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy

D. Caselli, S. Cesaro, F. Fagioli, F. Carraro, Ottavio Ziino, Giulio Andrea Zanazzo, Cristina Meazza, Antonella Colombini, Elio Castagnola, Paola Muggeo, Rossella Mura, M. G. Orofino, M. Giacchino, M. La Spina, Caterina Consarino, Fabio Tucci, Angelica Barone, M. Cellini, K. Perruccio, Roberto BandettiniR. Rondelli, S. De Masi, Maurizio Aricò

Research output: Contribution to journal › Article › peer-review

Abstract

Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.

Original language	English
Pages (from-to)	152-155
Number of pages	4
Journal	Infectious Diseases
Volume	48
Issue number	2
DOIs	https://doi.org/10.3109/23744235.2015.1087647
Publication status	Published - 2016

Keywords

Cancer
Carbapenemase-producing Enterobacteriaceae
Children
Immunosuppression
Klebsiella pneumoniae carbapenemase

ASJC Scopus subject areas

Infectious Diseases
Immunology and Microbiology(all)
Microbiology (medical)

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Caselli, D., Cesaro, S., Fagioli, F., Carraro, F., Ziino, O., Zanazzo, G. A., Meazza, C., Colombini, A., Castagnola, E., Muggeo, P., Mura, R., Orofino, M. G., Giacchino, M., La Spina, M., Consarino, C., Tucci, F., Barone, A., Cellini, M., Perruccio, K., ... Aricò, M. (2016). Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy. Infectious Diseases, 48(2), 152-155. https://doi.org/10.3109/23744235.2015.1087647

Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy. / Caselli, D.; Cesaro, S.; Fagioli, F.; Carraro, F.; Ziino, Ottavio; Zanazzo, Giulio Andrea; Meazza, Cristina; Colombini, Antonella; Castagnola, Elio; Muggeo, Paola; Mura, Rossella; Orofino, M. G.; Giacchino, M.; La Spina, M.; Consarino, Caterina; Tucci, Fabio; Barone, Angelica; Cellini, M.; Perruccio, K.; Bandettini, Roberto; Rondelli, R.; De Masi, S.; Aricò, Maurizio.

In: Infectious Diseases, Vol. 48, No. 2, 2016, p. 152-155.

Research output: Contribution to journal › Article › peer-review

Caselli, D, Cesaro, S, Fagioli, F, Carraro, F, Ziino, O, Zanazzo, GA, Meazza, C, Colombini, A, Castagnola, E, Muggeo, P, Mura, R, Orofino, MG, Giacchino, M, La Spina, M, Consarino, C, Tucci, F, Barone, A, Cellini, M, Perruccio, K, Bandettini, R, Rondelli, R, De Masi, S & Aricò, M 2016, 'Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy', Infectious Diseases, vol. 48, no. 2, pp. 152-155. https://doi.org/10.3109/23744235.2015.1087647

Caselli, D. ; Cesaro, S. ; Fagioli, F. ; Carraro, F. ; Ziino, Ottavio ; Zanazzo, Giulio Andrea ; Meazza, Cristina ; Colombini, Antonella ; Castagnola, Elio ; Muggeo, Paola ; Mura, Rossella ; Orofino, M. G. ; Giacchino, M. ; La Spina, M. ; Consarino, Caterina ; Tucci, Fabio ; Barone, Angelica ; Cellini, M. ; Perruccio, K. ; Bandettini, Roberto ; Rondelli, R. ; De Masi, S. ; Aricò, Maurizio. / Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy. In: Infectious Diseases. 2016 ; Vol. 48, No. 2. pp. 152-155.

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title = "Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy",

abstract = "Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.",

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AU - Barone, Angelica

AU - Cellini, M.

AU - Perruccio, K.

AU - Bandettini, Roberto

AU - Rondelli, R.

AU - De Masi, S.

AU - Aricò, Maurizio

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Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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