Abstract
Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.
Original language | English |
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Pages (from-to) | 152-155 |
Number of pages | 4 |
Journal | Infectious Diseases |
Volume | 48 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- Cancer
- Carbapenemase-producing Enterobacteriaceae
- Children
- Immunosuppression
- Klebsiella pneumoniae carbapenemase
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Microbiology(all)
- Microbiology (medical)