Abstract
Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.
| Original language | English |
|---|---|
| Pages (from-to) | 152-155 |
| Number of pages | 4 |
| Journal | Infectious Diseases |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Cancer
- Carbapenemase-producing Enterobacteriaceae
- Children
- Immunosuppression
- Klebsiella pneumoniae carbapenemase
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Microbiology(all)
- Microbiology (medical)
Cite this
Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy. / Caselli, D.; Cesaro, S.; Fagioli, F.; Carraro, F.; Ziino, Ottavio; Zanazzo, Giulio Andrea; Meazza, Cristina; Colombini, Antonella; Castagnola, Elio; Muggeo, Paola; Mura, Rossella; Orofino, M. G.; Giacchino, M.; La Spina, M.; Consarino, Caterina; Tucci, Fabio; Barone, Angelica; Cellini, M.; Perruccio, K.; Bandettini, Roberto; Rondelli, R.; De Masi, S.; Aricò, Maurizio.
In: Infectious Diseases, Vol. 48, No. 2, 2016, p. 152-155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy
AU - Caselli, D.
AU - Cesaro, S.
AU - Fagioli, F.
AU - Carraro, F.
AU - Ziino, Ottavio
AU - Zanazzo, Giulio Andrea
AU - Meazza, Cristina
AU - Colombini, Antonella
AU - Castagnola, Elio
AU - Muggeo, Paola
AU - Mura, Rossella
AU - Orofino, M. G.
AU - Giacchino, M.
AU - La Spina, M.
AU - Consarino, Caterina
AU - Tucci, Fabio
AU - Barone, Angelica
AU - Cellini, M.
AU - Perruccio, K.
AU - Bandettini, Roberto
AU - Rondelli, R.
AU - De Masi, S.
AU - Aricò, Maurizio
PY - 2016
Y1 - 2016
N2 - Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.
AB - Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.
KW - Cancer
KW - Carbapenemase-producing Enterobacteriaceae
KW - Children
KW - Immunosuppression
KW - Klebsiella pneumoniae carbapenemase
UR - http://www.scopus.com/inward/record.url?scp=84962238468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962238468&partnerID=8YFLogxK
U2 - 10.3109/23744235.2015.1087647
DO - 10.3109/23744235.2015.1087647
M3 - Article
VL - 48
SP - 152
EP - 155
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 2
ER -