Incidence of critical limb ischemia and amputation outcome in contralateral limb in diabetic patients hospitalized for unilateral critical limb ischemia during 1999-2003 and followed-up until 2005

Ezio Faglia, Giacomo Clerici, Manuela Mantero, Maurizio Caminiti, Antonella Quarantiello, Vincenzo Curci, Alberto Morabito

Research output: Contribution to journalArticle

Abstract

We studied the incidence of critical limb ischemia (CLI) and amputation outcome of the contralateral limb in 533 diabetic patients hospitalized in our diabetic foot centre because of CLI from 1999 to 2003 and followed-up until 2005. The cumulative incidence rate during the 6-year period reached 49.8% (CI confidence interval = 40.6-59.6). All patients underwent arteriography and in 181 (98.4%) the revascularization was performed without different feasibility (p = 0.077) compared to that (95.3%) in the initial patients. The severity of lesion evaluated with Wagner grade was lower (χ2 = 33.5, p <0.001) and also the frequency of midfoot and above-the-ankle amputations was lower (p <0.001 and p = 0.022, respectively) in contralateral patients. There was no evidence from the logistic analysis to support the association between any of the investigated variables and incidence of CLI in the contralateral limb. Over a 6-year period, almost 50% of the diabetic patients with unilateral CLI developed a CLI in the contralateral limb: however, both severity of foot lesion and amputation level was significantly lower. This fact can be due to prompt therapeutic interventions, made possible thanks to an increased patient awareness acquired by training during the treatment of the unilateral limb.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume77
Issue number3
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Above-the-ankle amputation
  • Contralateral limb
  • Critical limb ischemia
  • Diabetic foot
  • Limb revascularization
  • Midfoot amputation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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