Incidence of febrile neutropenia and neutropenic infections in elderly patients receiving anthracycline-based chemotherapy for breast cancer without primary prophylaxis with colony-stimulating factors

A. Minisini, S. Spazzapan, D. Crivellari, M. Aapro, L. Biganzoli

Research output: Contribution to journalArticlepeer-review

Abstract

There is concern about the potential increase of hematological toxicity in elderly patients treated with chemotherapy. Recently, primary prophylaxis with colony-stimulating factors (CSFs) was proposed for elderly patients receiving moderately toxic chemotherapy. However, evidence for the benefits of this primary prophylaxis for elderly breast cancer patients is currently lacking. We retrospectively analyzed the incidence of febrile neutropenia (FN) and neutropenic infections in elderly breast cancer patients receiving anthracycline-based chemotherapy without primary prophylaxis with colony-stimulating factors. In addition, we assessed the direct costs of hospitalization for these complications. Febrile neutropenia or neutropenic infection occurred in 13% of the 46 patients. Further studies are needed to adequately evaluate the risk of neutropenic complications (NC) in elderly patients receiving standard-dose chemotherapy for breast cancer and the potential benefits of primary prophylaxis with colony-stimulating factors.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume53
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Breast cancer
  • Chemotherapy
  • Elderly
  • Febrile nutropenia
  • G-CSF

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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