Incidence of high chromogranin A serum levels in patients with non metastatic prostate adenocarcinoma

Marialuisa Appetecchia, Aurela Meçule, Giuseppe Pasimeni, Concetta V. Iannucci, Piero De Carli, Roberto Baldelli, Agnese Barnabei, Giovanni Cigliana, Isabella Sperduti, Michele Gallucci

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Abstract

Background: ChromograninA in prostate carcinoma (PC) indicate NE differentiation. This tumour is more aggressive and resistant to hormone therapy. Patients and methods. We analyzed the incidence of pre-operative ChromograninA serum levels in non metastatic PC patients. Serum PSA and ChromograninA were analyzed before treatment. Clinicopathological parameters were evaluated in relation to serum ChromograninA. 486 patients were enrolled. Results. We found 352 pT2 and 134 pT3. 21 patients were N+. 278 patients had Gleason score levels 7. Median PSA pre-operative level was 7.61 ng/ml. PSA was significantly associated with pT stage (pT2 with PSA abnormal 23.6% vs pT3 48.5%, p <0.0001) and with a Gleason score (PSA abnormal 60% in the Gleason score was >7 vs 29.5% in the Gleason score = 7 vs 27.3% in the Gleason score 7 (31.4%) (p = 0.12). The serum ChromograninA levels in the two groups of patients were subdivided before and after 2005 on the basis of different used assays, showing no correlation with serum ChromograninA and other parameters. Conclusions. This study showed that ChromograninA levels correlated to NE differentiation and possible aggressiveness of PC. Pre-operative circulating ChromograninA could complement PSA in selecting more aggressive PC cases, particularly in the presence of a higher Gleason score. Complementary information is provided by the absence of a correlation between serum ChromograninA and PSA levels.

Original languageEnglish
Article number166
JournalJournal of Experimental and Clinical Cancer Research
Volume29
Issue number1
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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