Incidence of interval breast cancers after 650,000 negative mammographies in 13 Italian health districts

Lauro Bucchi, Alessandra Ravaioli, Flavia Foca, Americo Colamartini, Fabio Falcini, Carlo Naldoni

Research output: Contribution to journalArticle

Abstract

Objectives: To estimate the total proportional incidence of interval breast cancers in a two-yearly mammography screening programme, and to perform subgroup analyses by woman's age, screening centre-specific recall rate and screening round. Methods: Using unconverted electronic data-sets from the 13 screening centres in the Emilia-Romagna Region of northern Italy (540,450 women aged 50-69 years), a database of 919,538 mammography records was created. Of these, 655,175 eligible single-mammography records (1997-2002) from 379,318 women were record-linked with the regional Breast Cancer Registry. In the two-year inter-screening interval, a total of 1,022,694.3 woman-years at risk were accumulated, with 695 interval cancers observed and 2428.3 expected. The observed number of interval cancers was divided by the expected number to obtain the proportional incidence. Results: The total proportional incidence of first- and second-year interval cancers was 0.18 (95% CI 0.15-0.20) and 0.43 (0.39-0.47), respectively. Woman's age was inversely associated with proportional incidence in both interval years, with a cut-off point at age 60. A screening centre-specific recall rate greater than the regional average of 5% was associated with a proportional incidence of 0.14 (0.11-0.17) versus 0.20 (0.17-0.24) in the first interval year, and of 0.36 (0.31-0.41) versus 0.50 (0.44-0.56) in the second. The proportional incidence remained unchanged between the first and subsequent screening rounds. Conclusions: The results were in line with the previous Italian data and with the recommended European standards. The inverse effect of woman's age and of recall rate was expected.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalJournal of Medical Screening
Volume15
Issue number1
DOIs
Publication statusPublished - Mar 2008

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Mammography
Breast Neoplasms
Incidence
Health
Neoplasms
Italy
Registries
Databases

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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Incidence of interval breast cancers after 650,000 negative mammographies in 13 Italian health districts. / Bucchi, Lauro; Ravaioli, Alessandra; Foca, Flavia; Colamartini, Americo; Falcini, Fabio; Naldoni, Carlo.

In: Journal of Medical Screening, Vol. 15, No. 1, 03.2008, p. 30-35.

Research output: Contribution to journalArticle

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abstract = "Objectives: To estimate the total proportional incidence of interval breast cancers in a two-yearly mammography screening programme, and to perform subgroup analyses by woman's age, screening centre-specific recall rate and screening round. Methods: Using unconverted electronic data-sets from the 13 screening centres in the Emilia-Romagna Region of northern Italy (540,450 women aged 50-69 years), a database of 919,538 mammography records was created. Of these, 655,175 eligible single-mammography records (1997-2002) from 379,318 women were record-linked with the regional Breast Cancer Registry. In the two-year inter-screening interval, a total of 1,022,694.3 woman-years at risk were accumulated, with 695 interval cancers observed and 2428.3 expected. The observed number of interval cancers was divided by the expected number to obtain the proportional incidence. Results: The total proportional incidence of first- and second-year interval cancers was 0.18 (95{\%} CI 0.15-0.20) and 0.43 (0.39-0.47), respectively. Woman's age was inversely associated with proportional incidence in both interval years, with a cut-off point at age 60. A screening centre-specific recall rate greater than the regional average of 5{\%} was associated with a proportional incidence of 0.14 (0.11-0.17) versus 0.20 (0.17-0.24) in the first interval year, and of 0.36 (0.31-0.41) versus 0.50 (0.44-0.56) in the second. The proportional incidence remained unchanged between the first and subsequent screening rounds. Conclusions: The results were in line with the previous Italian data and with the recommended European standards. The inverse effect of woman's age and of recall rate was expected.",
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T1 - Incidence of interval breast cancers after 650,000 negative mammographies in 13 Italian health districts

AU - Bucchi, Lauro

AU - Ravaioli, Alessandra

AU - Foca, Flavia

AU - Colamartini, Americo

AU - Falcini, Fabio

AU - Naldoni, Carlo

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N2 - Objectives: To estimate the total proportional incidence of interval breast cancers in a two-yearly mammography screening programme, and to perform subgroup analyses by woman's age, screening centre-specific recall rate and screening round. Methods: Using unconverted electronic data-sets from the 13 screening centres in the Emilia-Romagna Region of northern Italy (540,450 women aged 50-69 years), a database of 919,538 mammography records was created. Of these, 655,175 eligible single-mammography records (1997-2002) from 379,318 women were record-linked with the regional Breast Cancer Registry. In the two-year inter-screening interval, a total of 1,022,694.3 woman-years at risk were accumulated, with 695 interval cancers observed and 2428.3 expected. The observed number of interval cancers was divided by the expected number to obtain the proportional incidence. Results: The total proportional incidence of first- and second-year interval cancers was 0.18 (95% CI 0.15-0.20) and 0.43 (0.39-0.47), respectively. Woman's age was inversely associated with proportional incidence in both interval years, with a cut-off point at age 60. A screening centre-specific recall rate greater than the regional average of 5% was associated with a proportional incidence of 0.14 (0.11-0.17) versus 0.20 (0.17-0.24) in the first interval year, and of 0.36 (0.31-0.41) versus 0.50 (0.44-0.56) in the second. The proportional incidence remained unchanged between the first and subsequent screening rounds. Conclusions: The results were in line with the previous Italian data and with the recommended European standards. The inverse effect of woman's age and of recall rate was expected.

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