TY - JOUR
T1 - Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy
AU - Baldin, Elisa
AU - Testoni, Stefania
AU - de Pasqua, Silvia
AU - Ferro, Salvatore
AU - Albani, Fiorenzo
AU - Baruzzi, Agostino
AU - D’Alessandro, Roberto
AU - Baruzzi, A.
AU - Albani, F.
AU - Calbucci, F.
AU - D’Alessandro, R.
AU - Michelucci, R.
AU - Brandes, A.
AU - Eusebi, V.
AU - Ceruti, S.
AU - Fainardi, E.
AU - Tamarozzi, R.
AU - Emiliani, E.
AU - Cavallo, M.
AU - Franceschi, E.
AU - Tosoni, A.
AU - Cavallo, M.
AU - Fiorica, F.
AU - Valentini, A.
AU - Depenni, R.
AU - Mucciarini, C.
AU - Crisi, G.
AU - Sasso, E.
AU - Biasini, C.
AU - Cavanna, L.
AU - Guidetti, D.
AU - Marcello, N.
AU - Pisanello, A.
AU - Cremonini, A. M.
AU - Guiducci, G.
AU - de Pasqua, S.
AU - Testoni, S.
AU - Agati, R.
AU - Ambrosetto, G.
AU - Bacci, A.
AU - Baldin, E.
AU - Baldrati, A.
AU - Barbieri, E.
AU - Bartolini, S.
AU - Bellavista, E.
AU - Bisulli, F.
AU - Franceschi, C.
AU - Mostacci, B.
AU - Riguzzi, P.
AU - Tinuper, Paolo
AU - On behalf of PERNO study group
PY - 2016
Y1 - 2016
N2 - Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.
AB - Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.
KW - Epidemiology
KW - Glioblastoma
KW - Incidence rate
KW - Primary brain tumors
KW - Survival
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U2 - 10.1007/s10072-016-2747-y
DO - 10.1007/s10072-016-2747-y
M3 - Article
C2 - PMID: 27807698
AN - SCOPUS:84994246305
SP - 1
EP - 8
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -